製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to MIIP
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 280-320 of Human MIIP

  • ポジティブ・コントロール
    • ZR-75-1 cell lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab103380 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 43 kDa.

ターゲット情報

  • 関連性
    MIIP has 3 SEG (segments of low compositional complexity) domains, an RGD motif, and several potential phosphorylation sites. The C-terminal region of IGFBP2 interacts with a central 44-amino acid sequence of MIIP. MIIP inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. It exhibits opposing effects to IGFBP2 on cell invasion. There are 2 named isoforms due to alternative splicing. Isoform 1 is expressed in brain but underexpressed in glioma tissues, at protein level. Isoform 2 is not detected in normal organs, but is expressed in gliomas with increasing levels with glioma progression. On the contrary, at protein level, isoform 2 is not detected in gliomas, suggesting that this isoform is unstable in glioma cells. Isoform 2 is degraded by the ubiquitin-proteasome pathway.
  • 参照データベース
  • 別名
    • FLJ12438 antibody
    • FLJ38609 antibody
    • IGFBP 2 binding protein antibody
    • IGFBP2 binding protein antibody
    • IIP45 antibody
    • Invasion inhibitory protein 45 antibody
    • Migration and invasion inhibitory protein antibody
    • RP5 1077B9.4 antibody
    see all

画像

  • Anti-MIIP antibody (ab103380) at 1/100 dilution + ZR-75-1 cell lysate at 35 µg

    Predicted band size : 43 kDa

プロトコール

参考文献

ab103380 has not yet been referenced specifically in any publications.

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