Anti-MICB 抗体 [MM0473-3C37] (ab90237)

製品の概要

  • 製品名Anti-MICB antibody [MM0473-3C37]
    MICB 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [MM0473-3C37] to MICB
  • アプリケーション適用あり: WB, Flow Cytmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant full length Human MICB.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: None
    Constituents: PBS
  • Concentration information loading...
  • 精製度Protein G purified
  • 特記事項(精製)The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and 0.2 µm filtered.
  • ポリ/モノモノクローナル
  • クローン名MM0473-3C37
  • アイソタイプIgG2b
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab90237 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Predicted molecular weight: 43 kDa.
Flow Cyt 1/20 - 1/200. ab170192-Mouse monoclonal IgG2b, is suitable for use as an isotype control with this antibody.

ターゲット情報

  • 機能Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
  • 組織特異性Widely expressed with the exception of the central nervous system where it is absent. Expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In hepatocellular carcinomas, expressed in tumor cells but not in surrounding non-cancerous tissue.
  • 関連疾患Genetic variations in MICA are a cause of susceptibility to rheumatoid arthritis (RA) [MIM:180300]. It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Note=The MICB*004 allele is associated with rheumatoid arthritis.
    Note=Genetic variation in MICB is associated with cytomegalovirus and herpes simplex virus I seropositivity and this may be associated with schizophrenia risk.
  • 配列類似性Belongs to the MHC class I family. MIC subfamily.
    Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
  • 翻訳後修飾Proteolytically cleaved and released from the cell surface of tumor cells.
  • 細胞内局在Cell membrane. Binding to human cytomegalovirus glycoprotein UL16 causes sequestration in the endoplasmic reticulum.
  • Information by UniProt
  • 参照データベース
  • 別名
    • MHC class I chain related protein B2 antibody
    • MHC class I mic B antigen antibody
    • MHC class I polypeptide related sequence B antibody
    • MHC class I polypeptide-related sequence B antibody
    • MIC B antibody
    • MIC-B antibody
    • MICB antibody
    • MICB_HUMAN antibody
    • PERB11.2 antibody
    see all

Anti-MICB antibody [MM0473-3C37] (ab90237) 使用論文

ab90237 has not yet been referenced specifically in any publications.

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