Anti-MICA + MICB 抗体 [6D4] (FITC) (ab46529)


  • 製品名Anti-MICA + MICB antibody [6D4] (FITC)
    MICA + MICB 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [6D4] to MICA + MICB (FITC)
  • 標識FITC. Ex: 493nm, Em: 528nm
  • 特異性This antibody is specific for non classical MICA and non classical MICB.
  • アプリケーション適用あり: Flow Cytmore details
  • 種交差性
    交差種: Human
  • 免疫原

    MICA transfected C1R cells.

  • 特記事項

    This antibody is reported to inhibit the cytotoxicity of NK cells stimulated by IFN alpha-treated dendritic cells.


  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C.
  • バッファーPreservative: 0.09% Sodium Azide
    Constituents: 1% BSA, PBS, pH 7.4
  • Concentration information loading...
  • 精製度Protein G purified
  • 一次抗体 備考This antibody is reported to inhibit the cytotoxicity of NK cells stimulated by IFN alpha-treated dendritic cells.
  • ポリ/モノモノクローナル
  • クローン名6D4
  • アイソタイプIgG2a
  • 研究分野


Our Abpromise guarantee covers the use of ab46529 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Flow Cyt Use 10µl for 106 cells. ab91362-Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.


  • 機能Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
  • 組織特異性Widely expressed with the exception of the central nervous system where it is absent. Expressed predominantly in gastric epithelium and also in monocytes, keratinocytes, endothelial cells, fibroblasts and in the outer layer of Hassal's corpuscles within the medulla of normal thymus. In skin, expressed mainly in the keratin layers, basal cells, ducts and follicles. Also expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In thyomas, overexpressed in cortical and medullar epithelial cells. Tumors expressing MICA display increased levels of gamma delta T-cells.
  • 関連疾患Anti-MICA antibodies and ligand shedding are involved in the progression of monoclonal gammopathy of undetermined significance (MGUS)to multiple myeloma.
    Psoriasis 1
    Psoriatic arthritis
  • 配列類似性Belongs to the MHC class I family. MIC subfamily.
    Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
  • 翻訳後修飾N-glycosylated. Glycosylation is not essential for interaction with KLRK1/NKG2D but enhances complex formation.
    Proteolytically cleaved and released from the cell surface of tumor cells which impairs KLRK1/NKG2D expression and T-cell activation.
  • 細胞内局在Cell membrane. Cytoplasm. Expressed on the cell surface in gastric epithelium, endothelial cells and fibroblasts and in the cytoplasm in keratinocytes and monocytes. Infection with human adenovirus 5 suppresses cell surface expression due to the adenoviral E3-19K protein which causes retention in the endoplasmic reticulum.
  • Information by UniProt
  • 参照データベース
  • 別名
    • MHC class I chain-related protein A antibody
    • MHC class I chain-related protein B antibody
    • MHC class I polypeptide related sequence A antibody
    • MHC class I polypeptide related sequence B antibody
    • MHC class I polypeptide-related sequence A antibody
    • MIC-A antibody
    • micA antibody
    • MICA_HUMAN antibody
    • MICB antibody
    see all

Anti-MICA + MICB antibody [6D4] (FITC) (ab46529) 使用論文

ab46529 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab46529.
Please use the links above to contact us or submit feedback about this product.