製品の概要

  • 製品名
    Anti-MHC class I RT Ia antibody [OX-18]
  • 製品の詳細
    Mouse monoclonal [OX-18] to MHC class I RT Ia
  • 特異性
    Ab33752 recognises a monomorphic determinant of rat MHC Class I (RT1A), expressed by all rat strains. However, quantitative measurements suggest that not all of the class I molecules are recognised.
  • アプリケーション
    適用あり: Flow Cyt, ELISA, IHC-Fr, IPmore details
  • 種交差性
    交差種: Rat
  • 免疫原

    Rat spleen glycoproteins.

  • 特記事項


    This clone (OX-18) has been used in immunoaffinity purification of rat MHC class I molecules.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • バッファー
    Preservative: 0.09% Sodium Azide
    Constituents: PBS, pH 7.4
  • Concentration information loading...
  • 精製度
    Protein G purified
  • 特記事項(精製)
    This antibody was purified tissue culture supernatant.
  • 一次抗体 備考
    This clone (OX-18) has been used in immunoaffinity purification of rat MHC class I molecules.
  • ポリ/モノ
    モノクローナル
  • クローン名
    OX-18
  • ミエローマ
    P3x63-Ag8.653
  • アイソタイプ
    IgG1
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab33752 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Flow Cyt 1/10 - 1/50.

Use 10µl of this dilution for 106 cells in 100µl.





ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
ELISA Use at an assay dependent concentration.
IHC-Fr Use at an assay dependent concentration.

Acetone fixation recommended. The antigen is sensitive to fixation with paraformaldehyde.

IP Use at an assay dependent concentration.

ターゲット情報

  • 関連性
    The major histocompatibility complex (MHC) plays a central role in controlling immune responsiveness and susceptibility to a great variety of mainly autoimmune and infectious diseases. The mammalian MHC is usually divided into three regions, the class I, II, and III (also called central) gene regions, based on the genes contained therein. Class I regions encode the classical I (class Ia) and nonclassical I (class Ib) molecules. The widely expressed class Ia molecules perform the well described antigen presenting function to CD8 T lymphocytes, whereas the function of class Ib genes has largely remained unknown.
  • 細胞内局在
    Secreted
  • 参照データベース
  • 別名
    • RT1 class I gene (A 1) antibody
    • RT1 class I gene antibody
    • RT1 class Ia locus A antibody
    • RT1 class Ia, locus A (A1) antibody
    • RT1 class Ia, locus A1 antibody
    • RT1.A1(N) antibody
    • RT1A 1 antibody
    • RT1A1 antibody
    see all

参考文献

This product has been referenced in:
  • Heuer A  et al. hESC-derived neural progenitors prevent xenograft rejection through neonatal desensitisation. Exp Neurol 282:78-85 (2016). IHC ; Rat . Read more (PubMed: 27235932) »
  • Smits KM  et al. Preincubation of tumor cells with the anti-(MHC) class I antibody OX18 enhances tumor cell lysis by interleukin-2-activated NK cells. Transplant Proc 25:2806-7 (1993). Read more (PubMed: 8212242) »

See all 3 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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