Anti-MHC Class 1 H2 Db 抗体 [27-11-13] (ab25244)
製品の概要
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製品名Anti-MHC Class 1 H2 Db antibody [27-11-13]
MHC Class 1 H2 Db 一次抗体 製品一覧 -
製品の詳細Mouse monoclonal [27-11-13] to MHC Class 1 H2 Db
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特異性ab25244 recognizes the a3 domain of H2Db class I MHC antigen. The antibody cross-reacts with the a3 domain of H2Ld, H2Dq and H2Lq, but not H2Kd or H2Dd. Reactivity with haplotypes k, f, p, r, and s has not been observed.
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アプリケーション適用あり: Functional Studies, Flow Cyt, IHC-Frmore details
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種交差性交差種: Mouse
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免疫原
C3H.SW splenocytes (Mouse)
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エピトープRecognizes an epitope on the a chain of H2Db.
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特記事項
ab25244 can be used for complement-dependent cytoxicity assays.
製品の特性
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製品の状態Liquid
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保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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バッファーpH: 8.20
Constituent: 100% Borate buffered saline -
Concentration information loading... -
一次抗体 備考ab25244 can be used for complement-dependent cytoxicity assays.
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ポリ/モノモノクローナル
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クローン名27-11-13
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アイソタイプIgG2a
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軽鎖の種類kappa
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研究分野
関連製品
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Compatible Secondaries
アプリケーション
Our Abpromise guarantee covers the use of ab25244 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| Functional Studies | Use at an assay dependent concentration. Complement-dependent cytoxicity assay. |
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| Flow Cyt | Use at an assay dependent concentration. ab170191-Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody. | |
| IHC-Fr | Use at an assay dependent concentration. |
ターゲット情報
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関連性In the mouse the MHC Class 1 loci are called H2K, H2L and H2D. The equivalent loci in the human MHC are HLA (Human Leukocyte Antigen). MHC class I molecules are heterodimers, consisting of a single transmembrane polypeptide chain (the a-chain) which is highly polymorphic, and the invariant ß2 microglobulin (which is encoded elsewhere, not in the MHC). MHC class I molecules are found on almost every nucleated cell of the body. Their major function is to present peptide fragments derived from antigens to cytotoxic T cells.
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細胞内局在Cell Membrane; single pass type I membrane protein
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参照データベース
- Entrez Gene: 14964 Mouse
- SwissProt: P01899 Mouse
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別名
- H 2D cell surface glycoprotein antibody
- H2 class I histocompatibility antigen, DB alpha chain antibody
- H2D(B) antibody
see all
Anti-MHC Class 1 H2 Db antibody [27-11-13] (ab25244) 使用論文
This product has been referenced in:
- Dower SK et al. The interaction of monoclonal antibodies with MHC class I antigens on mouse spleen cells. I. Analysis of the mechanism of binding. J Immunol 132:751-8 (1984). Read more (PubMed: 6690617) »
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"