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製品の概要

  • 製品名mGlu Agonists Kit
    Metabotropic glutamate receptor キット 製品一覧
  • 特異性A collection of 7 agonists and modulators for a range of mGlu receptor subtypes. Products are freeze-dried as an exact weight so that addition of 1 ml or 0.5 ml of water provides a stock solution of 5 mM or 10 mM*, respectively.
    The kit contains (S)-3,5-DHPG (ab120007), (R,S)-CHPG sodium salt (ab120221), LY 379268 (ab120196), L-AP4 (ab120002), VU0155041 sodium salt (ab120248), AMN082 dihydrochloride (ab120011) and (S)-3,4-DCPG (ab120006). *Please note that AMN082 dihydrochloride (ab120011) is only soluble to 5 mM in water.
  • 製品の概要

    A collection of 7 agonists and modulators for a range of mGlu receptor subtypes. Products are freeze-dried as an exact weight so that addition of 1 ml or 0.5 ml of water provides a stock solution of 5 mM or 10 mM*, respectively.
    The kit contains (S)-3,5-DHPG (ab120007), (R,S)-CHPG sodium salt (ab120221), LY 379268 (ab120196), L-AP4 (ab120002), VU0155041 sodium salt (ab120248), AMN082 dihydrochloride (ab120011) and (S)-3,4-DCPG (ab120006). 

    *Please note that AMN082 dihydrochloride (ab120011) is only soluble to 5 mM in water. 

    Receptor

    Description. 

    mGlu1,5 

    (S)-3,5-DHPG:

    Selective group I mGlu agonist. 

    Suggested Solvent: Water 

    mGlu5 

    (R,S)-CHPG sodium salt:

    Water soluble form of (R,S)-CHPG (ab120039), a selective mGlu5 agonist. 

    Suggested Solvent: Water 

    mGlu2,3 

    LY379268:

    Highly potent and systemically active mGlu2 and mGlu3 agonist. EC50 values are 2.69 and 4.48 nM for hmGlu2 and hmGlu3, respectively and displays > 80-fold selectivity over group I and group III receptors. Effective in several animal models of stroke, epilepsy, drug abuse, schizophrenia, and pain. 

    Suggested Solvent: Water 

    mGlu4,6,7,8 (group III) 

    L-AP4:

    Selective group III mGlu receptor agonist. 

    Suggested Solvent: Water 

    mGlu4 

    VU0155041 sodium salt:

    Water soluble, positive allosteric selective modulator at mGluR4 (EC50 values are 798 nM and 693 nM at human and rat mGluR4 receptors, respectively). It has advantages over PHCCC (ab120043) as it is water soluble and more potent. Active in behavioural models of Parkinsons Disease. 

    Suggested Solvent: Water 

    mGlu7 

    AMN082 dihydrochloride:

    Potent, selective, orally active and brain penetrant mGlu7 receptor agonist. Potently inhibits cAMP accumulation and stimulates GTP binding (EC50 = 64-290 nM) in mGluR7 transfected cells. Selective over mGlu1, 2, 3, 4, 5, 6 and 8 and ionotropic receptors (up to 10 μM). Elevates plasma stress hormones in vivo. Induces mGlu7 receptor internalisation in dissociated hippocampal neurones. 

    Suggested Solvent: Water (5 mM) / DMSO (10 mM) 

    mGlu8 

    (S)-3,4-DCPG: 

    Potent, selective mGlu8a agonist (EC50 = 31 nM). Displays > 100-fold selectivity over mGlu7. Systemically active in vivo.

    Suggested Solvent: Water

  • 特記事項

    KIT

製品の特性

  • 関連性Metabotropic Glutamate Receptor contains a Periplasmic Binding Protein Type 1 region, which belongs to Type 1 periplasmic binding fold superfamily. This model and hierarchy represent the ligand binding domains of the LacI family of transcriptional regulators, periplasmic binding proteins of the ABC-type transport systems.
  • 別名
    • GluR
    • Smp_128940

mGlu Agonists Kit (ab120321) 使用論文

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