製品の概要

  • 製品名
    Mevastatin sodium salt
  • 製品の詳細
    HMG-CoA reductase inhibitor
  • 生理活性の詳細
    HMG-CoA reductase inhibitor (IC50 = 119.2 nM). Inhibits cholesterol biosynthesis. Demonstrates pro-apoptotic activity in vivo.
  • 精製度
    > 98%

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab120854 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Functional Studies Use at an assay dependent concentration.

画像

  • ab90529 staining cytochrome C in HepG2 cells treated with mevastatin sodium salt (ab120854), by ICC/IF. Increase of cytochrome C expression correlates with increased concentration of mevastatin sodium salt, as described in literature.
    The cells were incubated at 37°C for 4 hours in media containing different concentrations of ab120854 (mevastatin sodium salt) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab90529 (1 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

参考文献

This product has been referenced in:
  • Zhang S  et al. Activation of c-Jun N-terminal kinase is required for mevastatin-induced apoptosis of salivary adenoid cystic carcinoma cells. Anticancer Drugs 21:678-86 (2010). Read more (PubMed: 20629200) »
  • Perchellet JP  et al. Novel synthetic inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase activity that inhibit tumor cell proliferation and are structurally unrelated to existing statins. Int J Mol Med 24:633-43 (2009). Read more (PubMed: 19787197) »
  • Chakravarti R & Sahai V Compactin-a review. Appl Microbiol Biotechnol 64:618-24 (2004). Read more (PubMed: 15034683) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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