Anti-Methionine Aminopeptidase 2 抗体 (ab123266)

製品の概要

  • 製品名Anti-Methionine Aminopeptidase 2 antibody
    Methionine Aminopeptidase 2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Methionine Aminopeptidase 2
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide, corresponding to a region within N terminal amino acids 32-61 of Human Methionine Aminopeptidase 2 (NP_006829.1; UniProt ID: P50579), conjugated to KLH.

  • ポジティブ・コントロール
    • K562 cell lysate and 293 cell lysate, transiently transfected with Methionine Aminopeptidase 2.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab123266 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 53 kDa.

ターゲット情報

  • 機能Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.
    Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.
  • 配列類似性Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
  • 翻訳後修飾Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding.
  • 細胞内局在Cytoplasm. About 30% of expressed METAP2 associates with polysomes.
  • Information by UniProt
  • 参照データベース
  • 別名
    • A930035J23Rik antibody
    • AI047573 antibody
    • AL024412 antibody
    • Amp2 antibody
    • AU014659, antibody
    • EIF 2 associated p67 homolog antibody
    • EIF-2-associated p67 antibody
    • Initiation factor 2 associated 67 kDa glycoprotein antibody
    • Initiation factor 2-associated 67 kDa glycoprotein antibody
    • MAP 2 antibody
    • MAP2 antibody
    • MAP2_HUMAN antibody
    • MetAP 2 antibody
    • Metap2 antibody
    • Methionine aminopeptidase 2 antibody
    • Methionyl aminopeptidase 2 antibody
    • MGC102452 antibody
    • MGC127390 antibody
    • MGC53792 antibody
    • MNPEP antibody
    • p67 antibody
    • p67eIF2 antibody
    • Peptidase M antibody
    • Peptidase M2 antibody
    see all

Anti-Methionine Aminopeptidase 2 antibody 画像

  • Anti-Methionine Aminopeptidase 2 antibody (ab123266) at 1/100 dilution + K562 cell lysate at 35 µg

    Predicted band size : 53 kDa
  • All lanes : Anti-Methionine Aminopeptidase 2 antibody (ab123266) at 1/100 dilution

    Lane 1 : 293 cell lysate (non transfected)
    Lane 2 : 293 cell lysate (transiently transfected with Methionine Aminopeptidase 2)

    Lysates/proteins at 2 µg per lane.


    Predicted band size : 53 kDa

Anti-Methionine Aminopeptidase 2 antibody (ab123266) 使用論文

ab123266 has not yet been referenced specifically in any publications.

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