Anti-Metallophilic Macrophages 抗体 [MOMA-1] (Biotin) (ab51814)

製品の概要

  • 製品名Anti-Metallophilic Macrophages antibody [MOMA-1] (Biotin)
    Metallophilic Macrophages 一次抗体 製品一覧
  • 製品の詳細
    Rat monoclonal [MOMA-1] to Metallophilic Macrophages (Biotin)
  • 標識Biotin
  • 特異性Does not react with dendritic cells, peritoneal resident macrophages, peritoneal exudate cells, bone marrow or blood cells.
  • アプリケーション適用あり: IHC-Frmore details
    適用なし: IHC-P
  • 種交差性
    交差種: Mouse
  • 免疫原

    Mouse lymph node tissue

  • ポジティブ・コントロール
    • Mouse spleen
  • 特記事項The antigen is differentially induced in in vitro derived macrophages depending on the colony-stimulating factor applied (IL3 > M-CSF > GM-CSF). Distinct macrophage subpopulations of lymphoid organs express the antigen that reacts with this antibody. In the spleen, they are localized at the marginal sinus forming a ring around the periarteriolar lymphocyte sheath and follicular areas at the inner side of marginal zones. In lymph nodes, they are localized in the sinusoids and medullary cords, but not within follicular areas or paracortex. In Peyer’s patches they are localized in the interfollicular areas at the serosal side. Kupffer cells in the liver can be clearly stained. No reactive macrophages were found in the thymus, brain, kidney, liver, skin or heart. In non-lymphoid organs, the antigen is only found on a macrophage subpopulation in the lamina propria of the villi of the small intestine.


    Monoclonal antibody MOMA-1 is a useful marker for the identification of macrophage subpopulations in various organs, mostly characterized by a high level of non-specific esterase expression. Staining is particularly noteworthy with the metallophilic macrophages adjacent to the marginal zone of the spleen. MOMA-1 is also very suitable for differentiation of non-metallophilic marginal zone macrophages as detected by the monoclonal antibody ER-TR9 (ab51819). In addition, MOMA-1 detects macrophages at inflammatory sites and is positive with Kupffer cells.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • バッファーPreservative: 0.1% Kathon
    Constituents: PBS, 5mg/ml BSA, pH 7.2
  • Concentration information loading...
  • 精製度IgG fraction
  • 一次抗体 備考Monoclonal antibody MOMA-1 is a useful marker for the identification of macrophage subpopulations in various organs, mostly characterized by a high level of non-specific esterase expression. Staining is particularly noteworthy with the metallophilic macrophages adjacent to the marginal zone of the spleen. MOMA-1 is also very suitable for differentiation of non-metallophilic marginal zone macrophages as detected by the monoclonal antibody ER-TR9 (ab51819). In addition, MOMA-1 detects macrophages at inflammatory sites and is positive with Kupffer cells.
  • ポリ/モノモノクローナル
  • クローン名MOMA-1
  • アイソタイプIgG2a
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab51814 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-Fr Use a concentration of 0.5 - 1 µg/ml.
  • 追加情報Is unsuitable for IHC-P.
  • ターゲット情報

    • 関連性Metallophilic macrophages are a subpopulation of mature resident tissue macrophages. They show high non specific esterase activity and can be distinguished from splenic marginal zone macrophages by antibody staining and the lack of FITC-Ficoll uptake.

    Anti-Metallophilic Macrophages antibody [MOMA-1] (Biotin) 画像

    • ab51814 at 0.5 µg/ml staining mouse spleen; frozen tissue.

    Anti-Metallophilic Macrophages antibody [MOMA-1] (Biotin) (ab51814) 使用論文

    This product has been referenced in:
    • Khan TN  et al. Prolonged apoptotic cell accumulation in germinal centers of Mer-deficient mice causes elevated B cell and CD4+ Th cell responses leading to autoantibody production. J Immunol 190:1433-46 (2013). Mouse . Read more (PubMed: 23319738) »
    • Yamazaki C  et al. Critical roles of a dendritic cell subset expressing a chemokine receptor, XCR1. J Immunol 190:6071-82 (2013). Mouse . Read more (PubMed: 23670193) »

    See all 10 Publications for this product

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