Anti-Metabotropic Glutamate Receptor 6 抗体 (ab83576)

製品の概要

  • 製品名Anti-Metabotropic Glutamate Receptor 6 antibody
    Metabotropic Glutamate Receptor 6 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Metabotropic Glutamate Receptor 6
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Cow, Dog, Pig, Chimpanzee
  • 免疫原

    Synthetic peptide corresponding to a region within the N terminal amino acids 35-84 (AGGLTLGGLF PVHARGAAGR ACGQLKKEQG VHRLEAMLYA LDRVNADPEL) of Human Metabotropic Glutamate Receptor 6 (NP_000834).

  • ポジティブ・コントロール
    • 721_B cell lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab83576 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Detects a band of approximately 33, 95 kDa (predicted molecular weight: 95 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA Use at an assay dependent concentration.

ELISA titre using peptide based assay 1/312500.

ターゲット情報

  • 機能Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity.
  • 関連疾患Defects in GRM6 are the cause of congenital stationary night blindness type 1B (CSNB1B) [MIM:257270]. This disorder consits of a previously unrecognized, autosomal recessive form of congenital night blindness associated with a negative electroretinogram waveform. Patients are night blind from an early age, and when maximally dark-adapted, they could perceive lights only with an intensity equal to or slightly dimmer than that normally detected by the cone system. ERGs in response to single brief flashes of light have clearly detectable a-waves, which are derived from photoreceptors, and greatly reduced b-waves, which are derived from the second-order inner retinal neurons. ERGs in response to sawtooth flickering light indicate a markedly reduced ON response and a nearly normal OFF response. There is no subjective delay in the perception of suddenly appearing white vs black objects on a gray background.
  • 配列類似性Belongs to the G-protein coupled receptor 3 family.
  • 細胞内局在Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CSNB1B antibody
    • DKFZp686H1993 antibody
    • GluR6 antibody
    • Glutamate receptor metabotropic 6 antibody
    • GPRC1F antibody
    • Grm6 antibody
    • GRM6_HUMAN antibody
    • Metabotropic glutamate receptor 6 antibody
    • mGlu6 antibody
    • mGluR6 antibody
    see all

Anti-Metabotropic Glutamate Receptor 6 antibody 画像

  • Anti-Metabotropic Glutamate Receptor 6 antibody (ab83576) at 1 µg/ml + 721_B cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 95 kDa
    Observed band size : 33,95 kDa (why is the actual band size different from the predicted?)

Anti-Metabotropic Glutamate Receptor 6 antibody (ab83576) 使用論文

ab83576 has not yet been referenced specifically in any publications.

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