Anti-Metabotropic Glutamate Receptor 5 抗体 (ab27190)
Key features and details
- Rabbit polyclonal to Metabotropic Glutamate Receptor 5
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-Metabotropic Glutamate Receptor 5 antibody
Metabotropic Glutamate Receptor 5 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Metabotropic Glutamate Receptor 5 -
由来種
Rabbit -
アプリケーション
適用あり: IHC-Pmore details
適用なし: ICC -
種交差性
交差種: Human
交差が予測される動物種: Rabbit -
免疫原
Synthetic peptide within Human Metabotropic Glutamate Receptor 5 aa 1150 to the C-terminus. The exact sequence is proprietary.
Database link: P41594 -
ポジティブ・コントロール
- IHC: human brain tissue.
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特記事項
This product is FOR RESEARCH USE ONLY. For commercial use, please contact partnerships@abcam.com.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.60
Preservative: 0.1% Sodium azide
Constituents: PBS, 1% BSA -
Concentration information loading...
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精製度
Immunogen affinity purified -
特記事項(精製)
This antibody is an affinity purified IgG. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab27190の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
IHC-P |
1/50. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
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特記事項 |
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IHC-P
1/50. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. |
ターゲット情報
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機能
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. -
配列類似性
Belongs to the G-protein coupled receptor 3 family. -
細胞内局在
Cell membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 2915 Human
- Omim: 604102 Human
- SwissProt: P41594 Human
- Unigene: 147361 Human
- Unigene: 616625 Human
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別名
- Glutamate receptor metabotropic 5 antibody
- GPRC1E antibody
- Grm5 antibody
see all
画像
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (8)
ab27190 は 8 報の論文で使用されています。
- Guo Z et al. Prenatal immune activation potentiates endocannabinoid-related plasticity of inhibitory synapses in the hippocampus of adolescent rat offspring. Eur Neuropsychopharmacol 28:1405-1417 (2018). PubMed: 30257799
- Lum JS et al. A postmortem analysis of NMDA ionotropic and group 1 metabotropic glutamate receptors in the nucleus accumbens in schizophrenia. J Psychiatry Neurosci 43:102-110 (2018). PubMed: 29481317
- Lum JS et al. A postmortem analysis of NMDA ionotropic and group 1 metabotropic glutamate receptors in the nucleus accumbens in schizophrenia. J Psychiatry Neurosci 42:170077 (2017). PubMed: 29022871
- Dai J et al. Improved retinal function in RCS rats after suppressing the over-activation of mGluR5. Sci Rep 7:3546 (2017). PubMed: 28615682
- Matosin N et al. Metabotropic glutamate receptor 5 binding and protein expression in schizophrenia and following antipsychotic drug treatment. Schizophr Res 146:170-6 (2013). PubMed: 23462049
- Gleason KA et al. Susceptibility of the adolescent brain to cannabinoids: long-term hippocampal effects and relevance to schizophrenia. Transl Psychiatry 2:e199 (2012). PubMed: 23188199
- Ma L et al. Differential expression of group I metabotropic glutamate receptors in human motoneurons at low and high risk of degeneration in amyotrophic lateral sclerosis. Neuroscience 143:95-104 (2006). IHC-FoFr ; Human . PubMed: 16979830
- Tang VW Proteomic and bioinformatic analysis of epithelial tight junction reveals an unexpected cluster of synaptic molecules. Biol Direct 1:37 (2006). WB, ICC/IF ; Human . PubMed: 17156438