Anti-Metabotropic Glutamate Receptor 3 抗体 (ab10309)

製品の概要

  • 製品名Anti-Metabotropic Glutamate Receptor 3 antibody
    Metabotropic Glutamate Receptor 3 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Metabotropic Glutamate Receptor 3
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Rat
    交差が予測される動物種: Mouse, Human
  • 免疫原

    Synthetic peptide:

    TKVDEAEYM

    , corresponding to amino acids 118-126 of Rat metabotropic Glutamate Receptor 3.

  • ポジティブ・コントロール
    • Rat Cerebellar and cortical Membrane.
  • 特記事項


    L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: 0.1% Sodium Azide
    Constituents: 1.0% BSA, Tris-glycine. pH 7.8
  • 精製度Whole antiserum
  • 一次抗体 備考L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab10309 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000. Predicted molecular weight: 105.2 kDa. Using standard protocols the antibody has only been shown to work in systems using highly expressing transfected cells.

ターゲット情報

Anti-Metabotropic Glutamate Receptor 3 antibody 画像



  • Predicted band size : 105.2 kDa


    ab10309 at 1/1000 dilution by Western blot. Left image: rat cerebellar membrane. Right image: rat cortical membrane.

Anti-Metabotropic Glutamate Receptor 3 antibody (ab10309) 使用論文

This product has been referenced in:
  • García-Bea A  et al. Metabotropic glutamate receptor 3 (mGlu3; mGluR3; GRM3) in schizophrenia: Antibody characterisation and a semi-quantitative western blot study. Schizophr Res N/A:N/A (2016). WB . Read more (PubMed: 27130562) »

See 1 Publication for this product

Product Wall

Thank you for your enquiry. Testing has shown that this antibody does not cross react with mGluR2. Please contact us again if you require further assistance.

Yes. By Carl Romano's group and the antibody is specific for mGluR3.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"