Anti-Mesothelin 抗体 [SP74] (ab93620)

製品の概要

  • 製品名Anti-Mesothelin antibody [SP74]
    Mesothelin 一次抗体 製品一覧
  • 製品の詳細
    Rabbit monoclonal [SP74] to Mesothelin
  • アプリケーション適用あり: IHC-P, Flow Cytmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Pig
  • 免疫原

    A synthetic peptide corresponding to C-terminus of human Mesothelin protein.

  • ポジティブ・コントロール
    • Mesothelioma.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab93620 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use at an assay dependent concentration. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
Flow Cyt Use at an assay dependent concentration. ab172730-Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.

ターゲット情報

  • 機能Membrane-anchored forms may play a role in cellular adhesion.
    Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.
  • 組織特異性Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level).
  • 関連疾患Note=Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer.
  • 配列類似性Belongs to the mesothelin family.
  • 翻訳後修飾Both MPF and the cleaved form of mesothelin are N-glycosylated.
    Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin.
  • 細胞内局在Secreted and Cell membrane. Golgi apparatus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CAK 1 antibody
    • CAK1 antibody
    • CAK1 antigen antibody
    • cleaved form antibody
    • Megakaryocyte potentiating factor antibody
    • Mesothelin antibody
    • Mesothelin isoform 1 precursor antibody
    • MPF antibody
    • Msln antibody
    • MSLN_HUMAN antibody
    • Pre pro megakaryocyte potentiating factor antibody
    • Pre-pro-megakaryocyte-potentiating factor antibody
    • SMR antibody
    • SMRP antibody
    • Soluble MPF mesothelin related protein antibody
    see all

Anti-Mesothelin antibody [SP74] 画像

  • Flow cytometric analysis of rabbit anti-Mesothelin (SP74) antibody ab93620(1/100) in HeLa cells (green) compared to negative control of rabbit IgG (blue).

  • Ab93620 (1:100) staining Mesothelin in human esothelioma tissue by immunohistochemistry using formalin fixed, paraffin embedded tissue.

Anti-Mesothelin antibody [SP74] (ab93620) 使用論文

ab93620 has not yet been referenced specifically in any publications.

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The peptide from mybiosource is a different peptide immunogen than the one used to produce our product ab93620. As I mentioned the exact immunogen sequence used to produce ab93620 is considered proprietary by our supplying lab however this peptide...

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Unfortunately, we do not have any purified mesothelin for sale. I suggest consulting www.biocompare.com. It is a search service that has access to the catalogues of many companies, one of which may have the purified protein you need.

The exact immunogen sequence is confidential. However I can say it is located within aa520-606 of Q13421 (Uniprot).

Thanks for your reply.
This antibody is raised against a small synthetic peptide of 15-20 amino acids.
I hope this is the information you were looking for. Please contact me again if you have any further questions.

Thank you for your enquiry but I don't quite understand what you are asking. Are you looking for a blocking peptide?
Thanks in advance for clarification!

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"