Anti-Mesothelin 抗体 [PPI-2e(IHC)] (ab92347)

製品の概要

  • 製品名Anti-Mesothelin antibody [PPI-2e(IHC)]
    Mesothelin 一次抗体 製品一覧
  • 製品の詳細
    Rabbit monoclonal [PPI-2e(IHC)] to Mesothelin
  • アプリケーション適用あり: WBmore details
    適用なし: IHC-P or IP
  • 種交差性
    交差種: Human
  • 免疫原

    A synthetic peptide corresponding to residues near the C terminus of Human Mesothelin.

  • ポジティブ・コントロール
    • Fetal liver, uterus cancer, fetal pancreas and ovary cancer lysates.
  • 特記事項

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    This antibody detects full-length Mesothelin precursor (69 kDa) and the C terminal cleaved form of Mesothelin.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab92347 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000 - 1/10000. Predicted molecular weight: 69 kDa.Can be blocked with Mesothelin peptide (ab134675).
  • 追加情報Is unsuitable for IHC-P or IP.
  • ターゲット情報

    • 機能Membrane-anchored forms may play a role in cellular adhesion.
      Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.
    • 組織特異性Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level).
    • 関連疾患Note=Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer.
    • 配列類似性Belongs to the mesothelin family.
    • 翻訳後修飾Both MPF and the cleaved form of mesothelin are N-glycosylated.
      Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin.
    • 細胞内局在Secreted and Cell membrane. Golgi apparatus.
    • Information by UniProt
    • 参照データベース
    • 別名
      • CAK 1 antibody
      • CAK1 antibody
      • CAK1 antigen antibody
      • cleaved form antibody
      • Megakaryocyte potentiating factor antibody
      • Mesothelin antibody
      • Mesothelin isoform 1 precursor antibody
      • MPF antibody
      • Msln antibody
      • MSLN_HUMAN antibody
      • Pre pro megakaryocyte potentiating factor antibody
      • Pre-pro-megakaryocyte-potentiating factor antibody
      • SMR antibody
      • SMRP antibody
      • Soluble MPF mesothelin related protein antibody
      see all

    Anti-Mesothelin antibody [PPI-2e(IHC)] 画像

    • All lanes : Anti-Mesothelin antibody [PPI-2e(IHC)] (ab92347) at 1/1000 dilution

      Lane 1 : Fetal liver lysate
      Lane 2 : Uterus cancer lysate
      Lane 3 : Fetal pancreas lysate
      Lane 4 : Ovary cancer lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      HRP labelled goat anti-rabbit antibody at 1/2000 dilution

      Predicted band size : 69 kDa

    Anti-Mesothelin antibody [PPI-2e(IHC)] (ab92347) 使用論文

    ab92347 has not yet been referenced specifically in any publications.

    Product Wall

    I have good news today.

    We now added the blocking peptide for ab92347 to our catalog and it is available for purchase.

    ab134675

    http://www.abcam.com/index.html?datasheet=134675 (or use the following: http://www.abcam.com/i...

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    Thank you for your reply.

    I have to confirm that we do not have this peptide in our catalog at the moment. We are trying toadd this toour catalog but Ido not have any estimationwhen this will be available for your customer.

    Your cus...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"