製品の概要

  • 製品名Anti-Mesothelin antibody
    Mesothelin 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Mesothelin
  • 特異性Detects isoform 2.
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Horse, Cow, Cat, Dog, Pig
  • 免疫原

    Synthetic peptide corresponding to a region within the internal sequence amino acids 539-588 (QKLLGPHVEG LKAEERHRPV RDWILRQRQD DLDTLGLGLQ GGIPNGYLVL) of Human Mesothelin (NP_005814).

  • ポジティブ・コントロール
    • MCF7 cell lysate.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab83658 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Detects a band of approximately 39 kDa (predicted molecular weight: 32 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能Membrane-anchored forms may play a role in cellular adhesion.
    Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.
  • 組織特異性Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level).
  • 関連疾患Note=Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer.
  • 配列類似性Belongs to the mesothelin family.
  • 翻訳後修飾Both MPF and the cleaved form of mesothelin are N-glycosylated.
    Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin.
  • 細胞内局在Secreted and Cell membrane. Golgi apparatus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CAK 1 antibody
    • CAK1 antibody
    • CAK1 antigen antibody
    • cleaved form antibody
    • Megakaryocyte potentiating factor antibody
    • Mesothelin antibody
    • Mesothelin isoform 1 precursor antibody
    • MPF antibody
    • Msln antibody
    • MSLN_HUMAN antibody
    • Pre pro megakaryocyte potentiating factor antibody
    • Pre-pro-megakaryocyte-potentiating factor antibody
    • SMR antibody
    • SMRP antibody
    • Soluble MPF mesothelin related protein antibody
    see all

Anti-Mesothelin antibody 画像

  • Anti-Mesothelin antibody (ab83658) at 1 µg/ml (in 5% skim milk/ PBS) + MCF7 cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 32 kDa
    Observed band size : 39 kDa (why is the actual band size different from the predicted?)

Anti-Mesothelin antibody (ab83658) 使用論文

ab83658 has not yet been referenced specifically in any publications.

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