The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/750. Detects a band of approximately 180 kDa.
機能In case of filovirus infection, seems to function as a cell entry factor.
組織特異性Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines.
関連疾患Defects in MERTK are the cause of retinitis pigmentosa type 38 (RP38) [MIM:613862]. RP38 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
配列類似性Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily. Contains 2 fibronectin type-III domains. Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 protein kinase domain.
Xie S et al. Mer receptor tyrosine kinase is frequently overexpressed in human non-small cell lung cancer, confirming resistance to erlotinib. Oncotarget6:9206-19 (2015).
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Alciato F et al. TNF-alpha, IL-6, and IL-1 expression is inhibited by GAS6 in monocytes/macrophages. J Leukoc Biol87:869-75 (2010).
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