Anti-Melanoma Associated Antigen KBA.62 抗体 [KBA.62] (ab101138)

製品の概要

  • 製品名Anti-Melanoma Associated Antigen KBA.62 antibody [KBA.62]
  • 製品の詳細
    Mouse monoclonal [KBA.62] to Melanoma Associated Antigen KBA.62
  • アプリケーション適用あり: IHC-P, IHC-Frmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Human Melanoma Associated Antigen

  • ポジティブ・コントロール
    • Human Melanoma
  • 特記事項


    ab101138 is a novel anti-melanoma antibody. Studies thus far have shown a similar sensitivity to melanocytic proliferations as that seen with S100 protein staining, which is somewhat higher than that seen with HMB45. This has been confirmed by one study on a series of 215 sentinel lymph nodes. Moreover, ab101138 identified 6 patients (3%) who had confirmed sentinel lymph node metastasis but stained negative for HMB45. In this setting, the resolution appears to be higher than S100 protein in that the staining pattern (membranous) is quite distinct. Interestingly, most cases of desmoplastic and spindle cell melanomas show strongly positive results with ab101138, unlike that seen with other melanocyte markers. It should be noted that ab101138 will label occasional endothelial cells which can serve as an internal positive control. A small percentage of well differentiated squamous cell carcinomas of the skin (and lung) have also been noted to stain with this antibody; however, the poorly differentiated forms of carcinoma do not, thus resolving a greater practical problem in differential diagnosis. Therefore, ab101138 is a useful additional marker for melanoma, specifically in desmoplastic/spindle cell cases and in the context of micrometastasis in sentinel lymph node.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • バッファーPreservative: 0.1% Sodium Azide
    Constituents: PBS, BSA, pH 7.4
  • 精製度Tissue culture supernatant
  • 一次抗体 備考ab101138 is a novel anti-melanoma antibody. Studies thus far have shown a similar sensitivity to melanocytic proliferations as that seen with S100 protein staining, which is somewhat higher than that seen with HMB45. This has been confirmed by one study on a series of 215 sentinel lymph nodes. Moreover, ab101138 identified 6 patients (3%) who had confirmed sentinel lymph node metastasis but stained negative for HMB45. In this setting, the resolution appears to be higher than S100 protein in that the staining pattern (membranous) is quite distinct. Interestingly, most cases of desmoplastic and spindle cell melanomas show strongly positive results with ab101138, unlike that seen with other melanocyte markers. It should be noted that ab101138 will label occasional endothelial cells which can serve as an internal positive control. A small percentage of well differentiated squamous cell carcinomas of the skin (and lung) have also been noted to stain with this antibody; however, the poorly differentiated forms of carcinoma do not, thus resolving a greater practical problem in differential diagnosis. Therefore, ab101138 is a useful additional marker for melanoma, specifically in desmoplastic/spindle cell cases and in the context of micrometastasis in sentinel lymph node.
  • ポリ/モノモノクローナル
  • クローン名KBA.62
  • アイソタイプIgG1
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab101138 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/25 - 1/100.
IHC-Fr 1/25 - 1/100.

Anti-Melanoma Associated Antigen KBA.62 antibody [KBA.62] (ab101138) 使用論文

ab101138 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"