Anti-MEK3 抗体 - Aminoterminal end (ab70846)

製品の概要

  • 製品名Anti-MEK3 antibody - Aminoterminal end
    MEK3 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to MEK3 - Aminoterminal end
  • アプリケーション適用あり: ELISA, WB, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide selected from the N-terminal region of human MKK3 conjugated to KLH

  • ポジティブ・コントロール
    • Jurkat cell lysate, human breast carcinoma tissue

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab70846 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/1000.
WB 1/100 - 1/500. Detects a band of approximately 30 kDa (predicted molecular weight: 39 kDa).
IHC-P 1/50 - 1/100.

ターゲット情報

  • 機能Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38.
  • 組織特異性Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.
  • 関連疾患Note=Defects in MAP2K3 may be involved in colon cancer.
  • 配列類似性Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
    Contains 1 protein kinase domain.
  • 翻訳後修飾Autophosphorylated.
    Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases regulates positively the kinase activity.
    Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.
  • Information by UniProt
  • 参照データベース
  • 別名
    • AW212142 antibody
    • dual specificity mitogen activated protein kinase kinase 3 antibody
    • Dual specificity mitogen-activated protein kinase kinase 3 antibody
    • MAP kinase kinase 3 antibody
    • map2k3 antibody
    • MAPK ERK kinase 3 antibody
    • MAPK/ERK kinase 3 antibody
    • MAPKK 3 antibody
    • MAPKK3 antibody
    • MEK 3 antibody
    • MEK3 antibody
    • Mitogen activated protein kinase kinase 3 antibody
    • MKK 3 antibody
    • MKK3 antibody
    • mMKK3b antibody
    • MP2K3_HUMAN antibody
    • PRKMK 3 antibody
    • PRKMK3 antibody
    • protein kinase, mitogen-activated, kinase 3 antibody
    • SAPK kinase 2 antibody
    • SAPKK 2 antibody
    • SAPKK2 antibody
    • Stress activated protein kinase kinase 2 antibody
    see all

Anti-MEK3 antibody - Aminoterminal end 画像

  • Anti-MEK3 antibody - Aminoterminal end (ab70846) at 1/100 dilution + Jurkat cell lysate at 12.5 µg

    Secondary
    HRP-anti-rabbit
    Developed using the ECL technique

    Predicted band size : 39 kDa
    Observed band size : 30 kDa (why is the actual band size different from the predicted?)
  • Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with 1/50 ab70846. A peroxidase-conjugated secondary antibody, followed by AEC staining.

Anti-MEK3 antibody - Aminoterminal end (ab70846) 使用論文

ab70846 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab70846.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"