This fast track antibody is not yet fully characterized. It is subject to these terms and conditions

製品の概要

製品の特性

アプリケーション

  • 追加情報This antibody gave a positive result in ELISA against the immunizing peptide (ab60803).
    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway.
    • 組織特異性Ubiquitous.
    • 関連疾患Defects in MED12 are the cause of Opitz-Kaveggia syndrome (OKS) [MIM:305450]; also known as FG syndrome type 1 (FGS1) or FG syndrome (FGS). OKS is an X-linked disorder characterized by mental retardation, relative macrocephaly, hypotonia and constipation.
      Defects in MED12 are the cause of Lujan-Fryns syndrome (LUJFRYS) [MIM:309520]; also known as X-linked mental retardation with marfanoid habitus. Clinically, Lujan-Fryns syndrome can be distinguished from Opitz-Kaveggia syndrome by tall stature, hypernasal voice, hyperextensible digits and high nasal root.
    • 配列類似性Belongs to the Mediator complex subunit 12 family.
    • 細胞内局在Nucleus.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Activator recruited cofactor 240 kDa component antibody
      • Activator-recruited cofactor 240 kDa component antibody
      • ARC240 antibody
      • CAG repeat protein 45 antibody
      • CAGH45 antibody
      • HOPA antibody
      • KIAA0192 antibody
      • MED12 antibody
      • MED12_HUMAN antibody
      • Mediator complex subunit 12 antibody
      • Mediator of RNA polymerase II transcription subunit 12 antibody
      • OPA containing protein antibody
      • OPA-containing protein antibody
      • Thyroid hormone receptor associated protein complex 230 kDa component antibody
      • Thyroid hormone receptor-associated protein complex 230 kDa component antibody
      • TNRC11 antibody
      • Trap230 antibody
      • Trinucleotide repeat containing gene 11 protein antibody
      • Trinucleotide repeat-containing gene 11 protein antibody
      see all

    Anti-MED12 antibody (ab49053) 使用論文

    ab49053 has not yet been referenced specifically in any publications.

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