製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to Meckelin
  • アプリケーション
    適用あり: ICC/IF, WB, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic peptide derived from C terminal domain of human Meckelin.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファー
    Preservative: None
    Constituents: Whole serum
  • 精製度
    Whole antiserum
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab76786 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF Use at an assay dependent concentration. PubMed: 20512146
WB 1/100 - 1/1000. Predicted molecular weight: 112 kDa.
IHC-P 1/50 - 1/200.

ターゲット情報

  • 関連性
    Meckelin localizes to the primary cilium and to the plasma membrane. It functions in centriole migration to the apical membrane and formation of the primary cilium. Defects in the gene are a cause of Meckel syndrome type 3 (MKS3) and Joubert syndrome type 6 (JBTS6).
  • 細胞内局在
    Cell membrane; Multi-pass membrane protein
  • 参照データベース
  • 別名
    • JBTS6 antibody
    • Meckel syndrome type 3 protein antibody
    • MKS3 antibody
    • NPHP11 antibody
    • TMEM67 antibody
    • TNEM67 antibody
    • Transmembrane protein 67 antibody
    see all

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参考文献

This product has been referenced in:
  • Zhang M  et al. A missense mutation in TMEM67 causes Meckel-Gruber syndrome type 3 (MKS3): a family from China. Int J Clin Exp Pathol 8:5379-86 (2015). Read more (PubMed: 26191240) »
  • Valente EM  et al. Mutations in TMEM216 perturb ciliogenesis and cause Joubert, Meckel and related syndromes. Nat Genet : (2010). ICC/IF ; Human . Read more (PubMed: 20512146) »

See all 3 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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