製品の概要

  • 製品名Anti-MDFIC antibody
    MDFIC 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to MDFIC
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    KLH conjugated synthetic peptide selected from the N terminal region of Human MDFIC (NP_951038.1).

  • ポジティブ・コントロール
    • HeLa cell lysate

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab93224 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
ELISA
  • 追加情報ELISA: 1/1000.
    WB: 1/100 - 1/500. Predicted molecular weight: 37 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 関連性MDFIC is a cellular factor capable of modulating the expression of cellular and viral promoters. Its synthesis is controlled at the translational level by two different codons, an ATG and an upstream non-ATG translational initiator, allowing the production of two protein isoforms that present different subcellular localizations, p32 (isoform 2) being mainly distributed throughout the cytoplasm, whereas p40 (isoform 1) is targeted to the nucleolus. MDFIC is known to down-regulate Tat-dependent transcription of HIV-1 LTR by interacting with HIV-1 Tat and Rev proteins and impairing their nuclear import (possibly by rendering the NLS domains inaccessible to importin-beta) and stimulate activation of human T-cell leukaemia virus type I (HTLV-I) LTR. In human cells, MDFIC binds to the axin complex, resulting in an increase in the level of free beta-catenin; it affects axin regulation of the WNT and JNK signalling pathways.
    • 細胞内局在Cytoplasmic and Nuclear
    • 参照データベース
    • 別名
      • HIC antibody
      • Human I mfa domain containing protein antibody
      • Human I-mfa domain-Containing protein antibody
      • I mfa domain containing protein antibody
      • MyoD family inhibitor domain containing protein antibody
      • MyoD family inhibitor domain-containing protein antibody
      • p32 antibody
      • p40 antibody
      see all

    Anti-MDFIC antibody 画像

    • Anti-MDFIC antibody (ab93224) at 1/100 dilution + HeLa cell lysate at 35 µg

      Predicted band size : 37 kDa

    Anti-MDFIC antibody (ab93224) 使用論文

    ab93224 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab93224.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"