製品の概要

  • 製品名Anti-MDC antibody [EPR1362]
    MDC 一次抗体 製品一覧
  • 製品の詳細
    Rabbit monoclonal [EPR1362] to MDC
  • アプリケーション適用あり: WB, IHC-Pmore details
    適用なし: ICC/IF or IP
  • 種交差性
    交差種: Mouse
    非交差種: Rat, Human
  • 免疫原

    Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) corresponding to Mouse MDC aa 1 to the C-terminus.
    Database link: O88430

  • ポジティブ・コントロール
    • MDC full-length recombinant protein; Mouse colon tissue and mouse spleen tissues.
  • 特記事項

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • バッファーPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
  • 精製度Tissue culture supernatant
  • ポリ/モノモノクローナル
  • クローン名EPR1362
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab124768 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000 - 1/10000. Detects a band of approximately 8 kDa (predicted molecular weight: 10 kDa).
IHC-P 1/100 - 1/250. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. (Heat up to 98 degrees C, below boiling, and then let cool for 10-20 min).
  • 追加情報Is unsuitable for ICC/IF or IP.
  • ターゲット情報

    • 機能May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active.
    • 組織特異性Highly expressed in macrophage and in monocyte-derived dendritic cells, and thymus. Also found in lymph node, appendix, activated monocytes, resting and activated macrophages. Lower expression in lung and spleen. Very weak expression in small intestine. In lymph node expressed in a mature subset of Langerhans' cells (CD1a+ and CD83+). Expressed in Langerhans' cell histiocytosis but not in dermatopathic lymphadenopathy. Expressed in atopic dermatitis, allergic contact dermatitis skin, and psoriasis, in both the epidermis and dermis.
    • 配列類似性Belongs to the intercrine beta (chemokine CC) family.
    • 翻訳後修飾The N-terminal processed forms MDC(3-69), MDC(5-69) and MDC(7-69) are produced by proteolytic cleavage after secretion from monocyte derived dendrocytes.
    • 細胞内局在Secreted.
    • Information by UniProt
    • 参照データベース
    • 別名
      • A 152E5.1 antibody
      • ABCD 1 antibody
      • ABCD1 antibody
      • C C motif chemokine 22 antibody
      • CC chemokine STCP 1 antibody
      • CC chemokine STCP-1 antibody
      • ccl 22 antibody
      • Ccl22 antibody
      • CCL22_HUMAN antibody
      • Chemokine (C C motif) ligand 22 antibody
      • DC/B CK antibody
      • DCBCK antibody
      • Macrophage-derived chemokine antibody
      • MDC antibody
      • MDC(1-69) antibody
      • MDC(7-69) antibody
      • MGC34554 antibody
      • SCYA22 antibody
      • Small inducible cytokine subfamily A (Cys Cys) member 22 antibody
      • Small inducible cytokine subfamily A, member 22 antibody
      • Small-inducible cytokine A22 antibody
      • STCP 1 antibody
      • STCP1 antibody
      • Stimulated T cell chemotactic protein 1 antibody
      • Stimulated T-cell chemotactic protein 1 antibody
      see all

    Anti-MDC antibody [EPR1362] 画像

    • Anti-MDC antibody [EPR1362] (ab124768) at 1/1000 dilution + Recombinant full-length MDC protein at 0.005 µg

      Secondary
      Goat anti-Rabbit HRP at 1/2000 dilution

      Predicted band size : 10 kDa
    • Immunohistochemical analysis of paraffin-embedded mouse colon tissue labeling MDC with ab124768 at 1/250 dilution followed by Goat Anti-Rabbit IgG H&L (HRP) (ab97051, 1/500). Counter stained with hematoxylin.

    • Immunohistochemical analysis of paraffin-embedded mouse spleen tissue labeling MDC with ab124768 at 1/250 dilution followed by Goat Anti-Rabbit IgG H&L (HRP) (ab97051, 1/500). Counter stained with hematoxylin.

    Anti-MDC antibody [EPR1362] (ab124768) 使用論文

    ab124768 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab124768.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"