製品の概要

  • 製品名Anti-MDA5 antibody
    MDA5 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to MDA5
  • アプリケーション適用あり: ELISA, IHC-P, Sandwich ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 929-1024 of Human MDA5 with proprietary tag (NP_071451).

  • ポジティブ・コントロール
    • Human placenta tissue.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab118377 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA Use at an assay dependent concentration.
IHC-P Use a concentration of 3 µg/ml.
Sandwich ELISA Use a concentration of 10 µg/ml.

ターゲット情報

  • 機能RNA helicase that, through its ATP-dependent unwinding of RNA, may function to promote message degradation by specific RNases. Seems to have growth suppressive properties. Involved in innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, triggers a transduction cascade involving MAVS/IPS1, which results in the activation of NF-kappa-B, IRF3 and IRF7 and the induction of the expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). ATPase activity is specifically induced by dsRNA. Essential for the production of interferons in response to picornaviruses.
  • 組織特異性Widely expressed, at a low level. Expression is detected at slightly highest levels in placenta, pancreas and spleen and at barely levels in detectable brain, testis and lung.
  • 関連疾患Genetic variation in IFIH1 is associated with diabetes mellitus insulin-dependent type 19 (IDDM19) [MIM:610155]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
    Note=IFIH1 is the CADM-140 autoantigen, involved in clinically amyopathic dermatomyositis (CADM). This is a chronic inflammatory disorder that shows typical skin manifestations of dermatomyositis but has no or little evidence of clinical myositis. Anti-CADM-140 antibodies appear to be specific to dermatomyositis, especially CADM. Patients with anti-CADM-140 antibodies frequently develop life-threatening acute progressive interstitial lung disease (ILD).
  • 配列類似性Belongs to the helicase family.
    Contains 2 CARD domains.
    Contains 1 helicase ATP-binding domain.
    Contains 1 helicase C-terminal domain.
  • 翻訳後修飾During apoptosis, processed into 3 cleavage products. The helicase-containing fragment, once liberated from the CARD domains, translocate from the cytoplasm to the nucleus. The processed protein significantly sensitizes cells to DNA degradation.
  • 細胞内局在Cytoplasm. Nucleus. May be found in the nucleus, during apoptosis.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CADM-140 autoantigen antibody
    • Clinically amyopathic dermatomyositis autoantigen 140 kDa antibody
    • DEAD/H (Asp Glu Ala Asp/His) box polypeptide antibody
    • DEAD/H box polypeptide antibody
    • Helicard antibody
    • Helicase with 2 CARD domains antibody
    • Hlcd antibody
    • IDDM 19 antibody
    • IDDM19 antibody
    • IFIH 1 antibody
    • Ifih1 antibody
    • IFIH1_HUMAN antibody
    • Interferon induced helicase C domain containing protein 1 antibody
    • interferon induced with helicase C domain 1 antibody
    • Interferon induced with helicase C domain protein 1 antibody
    • Interferon-induced helicase C domain-containing protein 1 antibody
    • Interferon-induced with helicase C domain protein 1 antibody
    • MDA 5 antibody
    • MDA-5 antibody
    • Melanoma differentiation associated protein 5 antibody
    • Melanoma differentiation-associated gene 5 antibody
    • Melanoma differentiation-associated protein 5 antibody
    • MGC133047 antibody
    • Murabutide down regulated protein antibody
    • Murabutide down-regulated protein antibody
    • RH 116 antibody
    • RH116 antibody
    • RIG I like receptor 2 antibody
    • RLR 2 antibody
    • RNA helicase DEAD box protein 116 antibody
    • RNA helicase-DEAD box protein 116 antibody
    see all

Anti-MDA5 antibody 画像

  • ab118377, at 3ug/ml, staining MDA5 in Formalin-fixed, Paraffin-embedded Human Placenta tissue by Immunohistochemistry.
  • Detection limit for recombinant tagged MDA5 is 3 ng/ml as a capture antibody.

Anti-MDA5 antibody (ab118377) 使用論文

ab118377 has not yet been referenced specifically in any publications.

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