Anti-mMCP-4 抗体 (ab92368)
Key features and details
- Goat polyclonal to mMCP-4
- Suitable for: IHC-P
- Reacts with: Mouse
- Isotype: IgG
製品の概要
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製品名
Anti-mMCP-4 antibody -
製品の詳細
Goat polyclonal to mMCP-4 -
由来種
Goat -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Mouse -
免疫原
Synthetic peptide corresponding to Mouse mMCP-4 aa 114-126 (internal sequence) (Cysteine residue).
Sequence:KLQKKAKETPSVN
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA -
Concentration information loading...
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精製度
Immunogen affinity purified -
特記事項(精製)
ab92368 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab92368の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
IHC-P | (1) |
Use at an assay dependent concentration.
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特記事項 |
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IHC-P
Use at an assay dependent concentration. |
ターゲット情報
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機能
Has chymotrypsin-like activity. Hydrolyzes the amide bonds of synthetic substrates having Tyr and Phe residues at the P1 position. Preferentially hydrolyzes the 'Tyr-4-
-Ile-5' bond of angiotensin I and the 'Phe-20-
-Ala-21' bond of amyloid beta-protein, and is less active towards the 'Phe-8-
-His-9' bond of angiotensin I and the 'Phe-4-
-Ala-5' and 'Tyr-10-
-Glu-11' bonds of amyloid beta-protein. Involved in thrombin regulation and fibronectin processing. -
組織特異性
Submucosal mast cells. In femoral muscle, detected in myocytes but not in mast cells. -
配列類似性
Belongs to the peptidase S1 family. Granzyme subfamily.
Contains 1 peptidase S1 domain. - Information by UniProt
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参照データベース
- Entrez Gene: 17227 Mouse
- SwissProt: P21812 Mouse
- Unigene: 439684 Mouse
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別名
- Mast cell protease 4 antibody
- Mcp 4 antibody
- Mcpt4 antibody
see all
データシートおよび資料
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Datasheet download
参考文献 (3)
ab92368 は 3 報の論文で使用されています。
- Terai K et al. Mechanism of Albuminuria Reduction by Chymase Inhibition in Diabetic Mice. Int J Mol Sci 21:N/A (2020). PubMed: 33050674
- Mackey E et al. Perinatal androgens organize sex differences in mast cells and attenuate anaphylaxis severity into adulthood. Proc Natl Acad Sci U S A 117:23751-23761 (2020). PubMed: 32917815
- Rowbotham SP et al. H3K9 methyltransferases and demethylases control lung tumor-propagating cells and lung cancer progression. Nat Commun 9:4559 (2018). PubMed: 30455465