製品の概要

  • 製品名Anti-MCM3 antibody
    MCM3 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to MCM3
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Mouse, Human
    交差が予測される動物種: Horse, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan
  • 免疫原

    Synthetic peptide corresponding to a region between residues 500 and 550 of human MCM3 (NP_002379.2).

  • ポジティブ・コントロール
    • human colon adenocarcinoma tissue; mouse squamous cell carcinoma tissue.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーPreservative: 0.09% Sodium Azide
    Constituents: 0.1% BSA, Tris buffered saline
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)Antibody was affinity purified using an epitope specific to MCM3 immobilized on solid support.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab84491 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P
  • 追加情報IHC-P: 1/100 - 1/500.

    Epitope exposure is recommended.
    Epitope exposure with citrate buffer will enhance staining.
    Likely to work with frozen sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation.
    • 配列類似性Belongs to the MCM family.
      Contains 1 MCM domain.
    • 翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 細胞内局在Nucleus.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Cervical cancer proto oncogene 5 antibody
      • DNA polymerase alpha holoenzyme associated P1 antibody
      • DNA polymerase alpha holoenzyme associated protein P1 antibody
      • DNA polymerase alpha holoenzyme-associated protein P1 antibody
      • DNA replication factor MCM3 antibody
      • DNA replication licensing factor mcm3 antibody
      • HCC 5 antibody
      • HCC5 antibody
      • hRlf beta subunit antibody
      • Human cervical cancer proto oncogene 5 antibody
      • MCM 3 antibody
      • mcm3 antibody
      • MCM3 minichromosome maintenance deficient 3 antibody
      • MCM3_HUMAN antibody
      • MGC1157 antibody
      • Minichromosome maintenance complex component 3 antibody
      • Minichromosome maintenance deficient 3 antibody
      • Minichromosome maintenance protein 3 antibody
      • P1 h antibody
      • P1 MCM3 antibody
      • P1 Protein antibody
      • P1-MCM3 antibody
      • P1.h antibody
      • p102 antibody
      • P102 protein antibody
      • Replication licensing factor beta subunit antibody
      • RLF beta subunit antibody
      • RLF subunit beta antibody
      • RLFB antibody
      see all

    Anti-MCM3 antibody 画像

    • IHC analysis of FFPE section of human colon adenocarcinoma using ab84491 at a dilution of 1/250.
    • IHC analysis of FFPE section of mouse squamous cell carcinoma using ab84491 at a dilution of 1/250.

    Anti-MCM3 antibody (ab84491) 使用論文

    ab84491 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab84491.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"