製品の概要

  • 製品名Anti-MCFD2 antibody
    MCFD2 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to MCFD2
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant full length protein, corresponding to amino acids 1-147 of Human MCFD2

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • 精製度Protein G purified
  • ポリ/モノモノクローナル
  • アイソタイプIgG2a
  • 軽鎖の種類kappa
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab57843 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
IHC-P
  • 追加情報WB: Use at a concentration of 1-5 µg/ml.
    IHC-P: Use at a concentration of 3 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Plays a role in the secretion of coagulation factors.
    • 関連疾患Defects in MCFD2 are a cause of factor V and factor VIII combined deficiency type 2 (F5F8D2) [MIM:613625]; also known as multiple coagulation factor deficiency 2 (MCFD2). F5F8D2 is a blood coagulation disorder characterized by bleeding symptoms similar to those in hemophilia or parahemophilia, that are caused by single deficiency of FV or FVIII, respectively. The most common symptoms are epistaxis, menorrhagia, and excessive bleeding during or after trauma. Plasma levels of coagulation factors V and VIII are in the range of 5 to 30% of normal.
    • 配列類似性Contains 2 EF-hand domains.
    • ドメインEssentially unstructured in the absence of calcium ions. Requires calcium ions for folding.
    • 細胞内局在Endoplasmic reticulum-Golgi intermediate compartment. Endoplasmic reticulum. Golgi apparatus.
    • Information by UniProt
    • 参照データベース
    • 別名
      • 1810021C21Rik antibody
      • DKFZp686G21263 antibody
      • F5F8D antibody
      • LMAN1IP antibody
      • MCFD 2 antibody
      • Mcfd2 antibody
      • MCFD2_HUMAN antibody
      • Multiple coagulation factor deficiency protein 2 antibody
      • Neural stem cell derived neuronal survival protein antibody
      • Neural stem cell-derived neuronal survival protein antibody
      • SDNSF antibody
      see all

    Anti-MCFD2 antibody 画像

    • MCFD2 antibody (ab57843) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human ovary, clear cell carcinoma.
    • Western blot against tagged recombinant protein immunogen using ab57843 MCFD2 antibody at 1ug/ml. Predicted band size of immunogen is 42 kDa

    Anti-MCFD2 antibody (ab57843) 使用論文

    ab57843 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab57843.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"