製品の概要

  • 製品名Anti-MCAF1 antibody
    MCAF1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to MCAF1
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Mouse, Human
    交差が予測される動物種: Horse, Cow, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Elephant
  • 免疫原

    Synthetic peptide corresponding to a region between residues 25 and 100 of Human MCAF1 (AAQ92978.1).

  • ポジティブ・コントロール
    • Human small cell lung cancer. Mouse squamous cell carcinoma.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab84497 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P
  • 追加情報IHC-P: 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 関連性MCAF1 is a recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. It can act both as an activator or a repressor depending on the context. It mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. MCAF1 is required to stimulate histone methyltransferase activity of SETDB1 and facilitate the conversion of dimethylated to trimethylated H3 'Lys-9'. The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation.
    • 細胞内局在Nuclear
    • 参照データベース
    • 別名
      • Activating transcription factor 7 interacting protein 1 antibody
      • ATF interacting protein antibody
      • ATF IP antibody
      • ATF7IP antibody
      • ATFa associated modulator antibody
      • FLJ10139 antibody
      • FLJ10688 antibody
      • hAM antibody
      • HGNC:20092 antibody
      • MBD1 containing chromatin associated factor antibody
      • MCAF 1 antibody
      • MCAF antibody
      • p621 antibody
      see all

    Anti-MCAF1 antibody 画像

    • ab84497, at 1/250 dilution, staining MCAF1 in formalin-fixed, paraffin-embedded human small cell lung cancer by Immunohistochemistry, using DAB staining.
    • ab84497, at 1/250 dilution, staining MCAF1 in formalin-fixed, paraffin-embedded mouse squamous cell carcinoma by Immunohistochemistry, using DAB staining.

    Anti-MCAF1 antibody (ab84497) 使用論文

    This product has been referenced in:
    • Minkovsky A  et al. The Mbd1-Atf7ip-Setdb1 pathway contributes to the maintenance of X chromosome inactivation. Epigenetics Chromatin 7:12 (2014). Mouse . Read more (PubMed: 25028596) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"