製品の概要

  • 製品名Anti-MAVS antibody
    MAVS 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to MAVS
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region between C terminal amino acids 476-505 of Human MAVS (NP_065797.2).

  • ポジティブ・コントロール
    • HeLa cell line lysates.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab116545 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 57 kDa.

ターゲット情報

  • 機能Required for innate immune defense against viruses. Acts downstream of DDX58 and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis.
  • 組織特異性Present in T-cells, monocytes, epithelial cells and hepatocytes (at protein level). Ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood leukocytes.
  • 配列類似性Contains 1 CARD domain.
  • ドメインBoth CARD and transmembrane domains are essential for antiviral function. The CARD domain is responsible for interaction with DDX58 and IFIH1.
  • 翻訳後修飾Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination catalyzed by ITCH; ITCH-dependent polyubiquitination is mediated by the interaction with PCBP2 and leads to MAVS proteasomal degradation.
  • 細胞内局在Mitochondrion outer membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CARD adapter inducing interferon beta antibody
    • CARD adaptor inducing IFN beta antibody
    • Cardif antibody
    • DKFZp666M015 antibody
    • FLJ27482 antibody
    • FLJ41962 antibody
    • IFN B promoter stimulator 1 antibody
    • Interferon beta promoter stimulator protein 1 antibody
    • Ips 1 antibody
    • IPS-1 antibody
    • Ips1 antibody
    • KIAA1271 antibody
    • MAVS antibody
    • MAVS_HUMAN antibody
    • Mitochondrial anti viral signaling protein antibody
    • Mitochondrial Antiviral Signaling antibody
    • Mitochondrial antiviral signaling protein antibody
    • Mitochondrial antiviral-signaling protein antibody
    • Putative NF kappa B activating protein 031N antibody
    • Putative NF-kappa-B-activating protein 031N antibody
    • Virus induced signaling adapter antibody
    • virus induced signaling adaptor antibody
    • Virus-induced-signaling adapter antibody
    • VISA antibody
    see all

Anti-MAVS antibody 画像

  • Anti-MAVS antibody (ab116545) at 1/100 dilution + HeLa cell line lysates at 35 µg

    Predicted band size : 57 kDa

Anti-MAVS antibody (ab116545) 使用論文

ab116545 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab116545.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"