製品の概要

  • 製品名
    Anti-Matriptase 2 antibody
    Matriptase 2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Matriptase 2
  • 特異性
    ab56181 reacts with human Matripase 2 (TMPRSS6), and does not react with the other TMPRSSs. ab56181 recognizes all but the two truncated forms of Matripase 2.
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide corresponding to Human Matriptase 2. Synthetic peptide based on the CUB-2 domain of Matripase 2.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab56181 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報
    WB: 1/1000 when using colorimetric substrates such as BCIP/NBT, and 1/5000 for chemiluminescent substrates. Predicted molecular weight: 89 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能
      Serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator with low efficiency. May play a specialized role in matrix remodeling processes in liver. Required to sense iron deficiency. Overexpression suppresses activation of the HAMP promoter.
    • 組織特異性
      Liver specific.
    • 関連疾患
      Defects in TMPRSS6 are the cause of iron-refractory iron deficiency anemia (IRIDA) [MIM:206200]; also known as hypochromic microcytic anemia with defect in iron metabolism or hereditary iron-handling disorder or pseudo-iron-deficiency anemia. Key features include congenital hypochromic microcytic anemia, very low mean corpuscular erythrocyte volume, low transferrin saturation, abnormal iron absorption characterized by no hematologic improvement following treatment with oral iron, and abnormal iron utilization characterized by a sluggish, incomplete response to parenteral iron.
    • 配列類似性
      Belongs to the peptidase S1 family.
      Contains 2 CUB domains.
      Contains 3 LDL-receptor class A domains.
      Contains 1 peptidase S1 domain.
    • ドメイン
      Cytoplasmic domain mediates HAMP suppression via proximal promoter element(s).
    • 細胞内局在
      Cell membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • IRIDA antibody
      • Matriptase-2 antibody
      • Membrane bound mosaic serine proteinase matriptase 2 antibody
      • Membrane type serine proteinase 2 antibody
      • MTSP 2 antibody
      • MTSP2 antibody
      • PVAE354 antibody
      • TMPRSS 6 antibody
      • TMPRSS6 antibody
      • TMPS6_HUMAN antibody
      • TMSP 6 antibody
      • TMSP6 antibody
      • Transmembrane protease serine 6 antibody
      • Type II Membrane Serine Proteinase 6 antibody
      see all

    画像

    • All lanes : Anti-Matriptase 2 antibody (ab56181) at 1/1000 dilution

      Lane 1 : Cell media from human embryonic kidney HEK293 cells
      Lane 2 : Cell media from human embryonic kidney HEK293 cells
      Lane 3 : Cell media from human embryonic kidney HEK293 cells


      Predicted band size : 89 kDa

    プロトコール

    参考文献

    ab56181 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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