製品の概要

  • 製品名Anti-Matriptase 2 antibody
    Matriptase 2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Matriptase 2
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Horse, Guinea pig, Cow, Cat, Dog, Pig
  • 免疫原

    Synthetic peptide, corresponding to a region within N-terminal amino acids 71-120 (LLWYFLGYKA EVMVSQVYSG SLRVLNRHFS QDLTRRESSA FRSETAKAQK) of Human Matriptase 2 (NP_705837).

  • ポジティブ・コントロール
    • Jurkat cell lysate

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab106842 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 90 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
IHC-P Use a concentration of 5 µg/ml.

ターゲット情報

  • 機能Serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator with low efficiency. May play a specialized role in matrix remodeling processes in liver. Required to sense iron deficiency. Overexpression suppresses activation of the HAMP promoter.
  • 組織特異性Liver specific.
  • 関連疾患Defects in TMPRSS6 are the cause of iron-refractory iron deficiency anemia (IRIDA) [MIM:206200]; also known as hypochromic microcytic anemia with defect in iron metabolism or hereditary iron-handling disorder or pseudo-iron-deficiency anemia. Key features include congenital hypochromic microcytic anemia, very low mean corpuscular erythrocyte volume, low transferrin saturation, abnormal iron absorption characterized by no hematologic improvement following treatment with oral iron, and abnormal iron utilization characterized by a sluggish, incomplete response to parenteral iron.
  • 配列類似性Belongs to the peptidase S1 family.
    Contains 2 CUB domains.
    Contains 3 LDL-receptor class A domains.
    Contains 1 peptidase S1 domain.
  • ドメインCytoplasmic domain mediates HAMP suppression via proximal promoter element(s).
  • 細胞内局在Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • IRIDA antibody
    • Matriptase-2 antibody
    • Membrane bound mosaic serine proteinase matriptase 2 antibody
    • Membrane type serine proteinase 2 antibody
    • MTSP 2 antibody
    • MTSP2 antibody
    • PVAE354 antibody
    • TMPRSS 6 antibody
    • TMPRSS6 antibody
    • TMPS6_HUMAN antibody
    • TMSP 6 antibody
    • TMSP6 antibody
    • Transmembrane protease serine 6 antibody
    • Type II Membrane Serine Proteinase 6 antibody
    see all

Anti-Matriptase 2 antibody 画像

  • Anti-Matriptase 2 antibody (ab106842) at 1 µg/ml + Jurkat cell lysate at 10 µg

    Predicted band size : 90 kDa
    12% SDS PAGE
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human liver tissue labelling Matriptase 2 with ab106842 at 5µg/ml.

Anti-Matriptase 2 antibody (ab106842) 使用論文

ab106842 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"