製品の概要

  • 製品名Anti-MARK4 antibody
    MARK4 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to MARK4
  • アプリケーション適用あり: ELISA, IHC-P, ICC/IFmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse
  • 免疫原

    Synthetic peptide, corresponding to an internal region of Human MARK4, conjugated to KLH.

  • ポジティブ・コントロール
    • Human tonsil tissue; A549 cells

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • バッファーpH: 7.40
    Preservative: 0.02% Sodium azide
    Constituents: 49% PBS, 50% Glycerol, 0.88% Sodium chloride
    Note: PBS is without Mg2+ and Ca2+
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab124267 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/40000.
IHC-P Use a concentration of 10 µg/ml.
ICC/IF 1/100 - 1/500.

ターゲット情報

  • 機能Serine/threonine-protein kinase (PubMed:15009667, PubMed:14594945, PubMed:23666762, PubMed:23184942). Phosphorylates the microtubule-associated protein MAPT (PubMed:14594945, PubMed:23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed:14594945). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (PubMed:14594945, PubMed:25123532). Required for the initiation of axoneme extension during cilium assembly (PubMed:23400999). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (PubMed:23400999). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (PubMed:25123532). Reduces neuronal cell survival (PubMed:15009667). Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (PubMed:23184942).
  • 組織特異性Ubiquitous. Isoform 2 is brain-specific (PubMed:11326310). Expressed at highest levels in brain and testis. Also expressed in heart, lung, liver, muscle, kidney and spleen (PubMed:14594945).
  • 配列類似性Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
    Contains 1 KA1 (kinase-associated) domain.
    Contains 1 protein kinase domain.
    Contains 1 UBA domain.
  • 発生段階Expressed at all stages of the mitotic cell cycle.
  • 翻訳後修飾Ubiquitinated with 'Lys-29'- and 'Lys-33'-linked polyubiquitins which appear to impede LKB1-mediated phosphorylation. Deubiquitinated by USP9X.
    Phosphorylated at Thr-214 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39 (PubMed:14976552). Phosphorylated throughout the cell cycle (PubMed:25123532).
  • 細胞内局在Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm. Localized at the tips of neurite-like processes in differentiated neuroblast cells. Detected in the cytoplasm and neuropil of the hippocampus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • FLJ90097 antibody
    • KIAA1860 antibody
    • MAP / microtubule affinity regulating kinase 4 antibody
    • MAP / microtubule affinity regulating kinase 4L antibody
    • MAP/microtubule affinity regulating kinase 4 antibody
    • MAP/microtubule affinity regulating kinase like 1 antibody
    • MAP/microtubule affinity-regulating kinase 4 antibody
    • MAP/microtubule affinity-regulating kinase-like 1 antibody
    • MARK 4 antibody
    • MARK 4L antibody
    • MARK L1 antibody
    • MARK4 antibody
    • MARK4 serine / threonine protein kinase antibody
    • MARK4 serine/threonine protein kinase antibody
    • MARK4_HUMAN antibody
    • MARK4S antibody
    • MARKL 1 antibody
    • MARKL1 antibody
    • Nbla00650 antibody
    • Putative protein product of Nbla00650 antibody
    see all

Anti-MARK4 antibody 画像

  • ab124267, at 10 µg/ml, staining MARK4 in formalin fixed, paraffin embedded Human tonsil tissue by immunohistochemistry.
  • ab124267, at a 1/100 dilution, staining MARK4 in A549 cells by Immunofluorescence. The picture on the right is treated with the synthesized peptide.

Anti-MARK4 antibody (ab124267) 使用論文

ab124267 has not yet been referenced specifically in any publications.

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