製品の概要

  • 製品名
  • 製品の詳細
    Goat polyclonal to MARK2
  • 特異性
    Expected to recognize both reported isoforms b and c (NP_004945.3 and NP_001034557.1).
  • アプリケーション
    適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Cow
  • 免疫原

    Synthetic peptide:

    C-QNGKDSTAPQR

    , corresponding to internal sequence amino acids 499-509 of Human MARK2 (NP_001034557.1)

  • ポジティブ・コントロール
    • Human Brain (Cerebellum) lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab77641 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
ELISA
  • 追加情報
    Peptide ELISA: Use at an assay dependent dilution. Antibody detection limit dilution: 1/16000.
    WB: Use at a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 70 kDa (predicted molecular weight: 77 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能
      Role in epithelial morphogenesis. Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. One or more isoforms may play a role in graft rejection.
    • 組織特異性
      High levels of expression in heart, brain, skeletal muscle and pancreas, lower levels observed in lung, liver and kidney.
    • 配列類似性
      Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. MARK subfamily.
      Contains 1 KA1 (kinase-associated) domain.
      Contains 1 protein kinase domain.
      Contains 1 UBA domain.
    • 細胞内局在
      Cell membrane. Phosphorylated by PRKCZ in polarized epithelial cells, resulting in an interaction with YWHAZ which promotes relocation from the lateral to the apical membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • ELKL motif kinase 1 antibody
      • ELKL motif kinase antibody
      • EMK-1 antibody
      • EMK1 antibody
      • MAP/microtubule affinity regulating kinase 2 antibody
      • MAP/microtubule affinity-regulating kinase 2 antibody
      • Mark2 antibody
      • MARK2_HUMAN antibody
      • MGC99619 antibody
      • PAR 1 antibody
      • Par 1b antibody
      • PAR1 homolog antibody
      • Par1b antibody
      • Ser/Thr protein kinase PAR 1B antibody
      • Serine/threonine protein kinase EMK antibody
      • Serine/threonine protein kinase MARK2 antibody
      • Serine/threonine-protein kinase MARK2 antibody
      see all

    画像

    プロトコール

    参考文献

    This product has been referenced in:
    • Lázaro-Diéguez F  et al. Par1b links lumen polarity with LGN-NuMA positioning for distinct epithelial cell division phenotypes. J Cell Biol 203:251-64 (2013). Read more (PubMed: 24165937) »

    See 1 Publication for this product

    レビューと Q&A

    There are currently no Customer reviews or Questions for ab77641.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

    登録