製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to MARCH9
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within the internal sequence amino acids 287-336 (SRTGPTSGAT SRPPAAQRMR TLLPQRCGYT ILHLLGQLRP PDARSSSHSG) of Human MARCH9 (NP_612405).

  • ポジティブ・コントロール
    • ACHN cell lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab99231 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 38 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 関連性
    MARCH9 (membrane-associated RING-CH protein IX) belongs to MARCH family, which contains at least seven membrane-associated RING-CH (MARCH)proteins. All MARCH proteins are ubiquitin ligases and located to subcellular membranes, and several MARCH proteins reduce surface levels of known substrates of the viral K3 family. Two closely related proteins, MARCH-IV and MARCH-IX, reduce surface expression of MHC-I molecules. In the presence of MARCH-IV or MARCH-IX, MHC-I are ubiquitinated and rapidly internalized by endocytosis. The functional similarity of the MARCH family and the K3 family of viral immune evasion proteins suggests that the viral immune evasion proteins were derived from MARCH proteins, a novel family of transmembrane ubiquitin ligases that seems to target glycoproteins for lysosomal destruction via ubiquitination of the cytoplasmic tail.
  • 細胞内局在
    Golgi apparatus membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
  • 参照データベース
  • 別名
    • BC019560 antibody
    • E3 ubiquitin protein ligase MARCH9 antibody
    • FLJ36578 antibody
    • MARCH IX antibody
    • Membrane associated RING CH protein IX antibody
    • membrane associated ring finger (C3HC4) 9 antibody
    • Membrane associated RING finger protein 9 antibody
    • RING finger protein 179 antibody
    • RNF179 antibody
    see all

画像

  • Anti-MARCH9 antibody (ab99231) at 1 µg/ml + ACHN cell lysate at 10 µg

    Predicted band size : 38 kDa

プロトコール

参考文献

ab99231 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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