製品の概要

  • 製品名Anti-MARCH9 antibody
    MARCH9 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to MARCH9
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Recombinant Fragment
    交差が予測される動物種: Mouse, Human
  • 免疫原

    A synthetic peptide corresponding to C-terminal residues of human MARCH9

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab56123 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 38 kDa. for 2 hours. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.
ELISA Use at an assay dependent dilution.

ターゲット情報

  • 関連性MARCH9 (membrane-associated RING-CH protein IX) belongs to MARCH family, which contains at least seven membrane-associated RING-CH (MARCH)proteins. All MARCH proteins are ubiquitin ligases and located to subcellular membranes, and several MARCH proteins reduce surface levels of known substrates of the viral K3 family. Two closely related proteins, MARCH-IV and MARCH-IX, reduce surface expression of MHC-I molecules. In the presence of MARCH-IV or MARCH-IX, MHC-I are ubiquitinated and rapidly internalized by endocytosis. The functional similarity of the MARCH family and the K3 family of viral immune evasion proteins suggests that the viral immune evasion proteins were derived from MARCH proteins, a novel family of transmembrane ubiquitin ligases that seems to target glycoproteins for lysosomal destruction via ubiquitination of the cytoplasmic tail.
  • 細胞内局在Golgi apparatus membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
  • 参照データベース
  • 別名
    • BC019560 antibody
    • E3 ubiquitin protein ligase MARCH9 antibody
    • FLJ36578 antibody
    • MARCH IX antibody
    • Membrane associated RING CH protein IX antibody
    • membrane associated ring finger (C3HC4) 9 antibody
    • Membrane associated RING finger protein 9 antibody
    • RING finger protein 179 antibody
    • RNF179 antibody
    see all

Anti-MARCH9 antibody (ab56123) 使用論文

ab56123 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"