製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to MARCH8
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Cow
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 1-50 (MSMPLHQISA IPSQDAISAR VYRSKTKEKE REEQNEKTLG HFMSHSSNIS) of Human MARCH8 (NP_001002265).

  • ポジティブ・コントロール
    • PANC1 cell lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab99229 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 33 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能
    E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS.
  • 組織特異性
    Broadly expressed. Present in immature dendritic cells (at protein level).
  • パスウェイ
    Protein modification; protein ubiquitination.
  • 配列類似性
    Contains 1 RING-CH-type zinc finger.
  • ドメイン
    The RING-CH-type zinc finger domain is required for E3 ligase activity.
  • 細胞内局在
    Cytoplasmic vesicle membrane. Lysosome membrane. Early endosome membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • c MIR antibody
    • c-MIR antibody
    • Cellular modulator of immune recognition antibody
    • E3 ubiquitin protein ligase MARCH8 antibody
    • E3 ubiquitin-protein ligase MARCH8 antibody
    • MARCH 8 antibody
    • MARCH VIII antibody
    • MARCH-VIII antibody
    • MARCH8 antibody
    • MARH8_HUMAN antibody
    • Membrane associated RING CH protein VIII antibody
    • Membrane associated ring finger (C3HC4) 8 antibody
    • Membrane associated RING finger protein 8 antibody
    • Membrane-associated RING finger protein 8 antibody
    • Membrane-associated RING-CH protein VIII antibody
    • MIR antibody
    • OTTHUMP00000058921 antibody
    • RING finger protein 178 antibody
    • RNF178 antibody
    see all

画像

  • Anti-MARCH8 antibody (ab99229) at 1 µg/ml + PANC1 cell lysate at 10 µg

    Predicted band size : 33 kDa

プロトコール

参考文献

ab99229 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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