製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to MARCH2
  • アプリケーション
    適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide corresponding to a region of human MARCH2

  • ポジティブ・コントロール
    • Jurkat cell lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab76397 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 27 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA Use at an assay dependent concentration.

Titre using peptide based assay, 1:312500.

ターゲット情報

  • 機能
    E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6.
  • 組織特異性
    Broadly expressed.
  • パスウェイ
    Protein modification; protein ubiquitination.
  • 配列類似性
    Contains 1 RING-CH-type zinc finger.
  • ドメイン
    The RING-CH-type zinc finger domain is required for E3 ligase activity.
  • 細胞内局在
    Endoplasmic reticulum membrane. Lysosome membrane. Endosome membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • E3 ubiquitin protein ligase MARCH2 antibody
    • E3 ubiquitin-protein ligase MARCH2 antibody
    • EC 6.3.2.- antibody
    • HSPC240 antibody
    • MARCH 2 antibody
    • MARCH II antibody
    • MARCH-II antibody
    • march2 antibody
    • MARH2_HUMAN antibody
    • Membrane associated RING CH protein II antibody
    • Membrane associated ring finger (C3HC4) 2 antibody
    • Membrane associated RING finger protein 2 antibody
    • Membrane-associated RING finger protein 2 antibody
    • Membrane-associated RING-CH protein II antibody
    • RING finger protein 172 antibody
    • RNF172 antibody
    see all

画像

プロトコール

参考文献

This product has been referenced in:
  • Han SO  et al. MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound ß(2)-adrenergic receptors. J Cell Biol 199:817-30 (2012). WB . Read more (PubMed: 23166351) »

See 1 Publication for this product

レビューと Q&A

There are currently no Customer reviews or Questions for ab76397.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

登録