製品の概要

  • 製品名
    Maprotiline hydrochloride
  • 製品の詳細
    Noradrenaline reuptake inhibitor
  • 生理活性の詳細
    Noradrenaline reuptake inhibitor. KD values are 11.1, 1000 and 5800 nM for noradrenaline, dopamine and serotonin transporters, respectively. Demonstrates 98% bioavailability following oral administration. Antidepressant activity in vivo.
  • 精製度
    > 99%

製品の特性

参考文献

This product has been referenced in:
  • Brachtendorf L  et al. Cytochrome P450 enzymes contributing to demethylation of maprotiline in man. Pharmacol Toxicol 90:144-9 (2002). Read more (PubMed: 12071336) »
  • Tatsumi M  et al. Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol 340:249-58 (1997). Read more (PubMed: 9537821) »
  • Baumann PA & Maître L Neurobiochemical aspects of maprotiline (Ludiomil) action. J Int Med Res 7:391-400 (1979). Read more (PubMed: 387493) »

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