機能Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment, by cytokines, or by environmental stress. Phosphorylates preferentially transcription factor ATF2.
組織特異性Highest levels in the brain and heart. Also expressed in the placenta, lung, liver, skeletal muscle, kidney and pancreas.
配列類似性Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. Contains 1 protein kinase domain.
ドメインThe TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
翻訳後修飾Dually phosphorylated on Thr-180 and Tyr-182, which activates the enzyme.