Chimpanzee, Gorilla, Orangutan
Synthetic peptide corresponding to Human MAP4K4 aa 550-600. A region between residue 550 and 600 of human MAP4K4. Database link: AAO32626.1
Human Colon Carcinoma, Prostate Carcinoma
特記事項The concentration of IgG is less than or equal to 1 mg/ml. For purposes where you wish to run a normal rabbit IgG as a control, assuming 1 mg/ml for the concentration of IgG in the IHC antibody is reasonable.
Immunoglobulin concentration was determined by extinction coefficient: absorbance at 280 nm of 1.4 equals 1.0 mg of IgG.
保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
バッファーPreservative: 0.09% Sodium Azide
Constituents: 0.1% BSA, Tris buffered saline
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精製度Immunogen affinity purified
特記事項（精製）Antibody was affinity purified using an epitope specific to MAP4K4 immobilized on solid support.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining. Likely to work with frozen sections. In some cases, the antibody may be diluted further than indicated.
機能Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway.
組織特異性Appears to be ubiquitous. Expressed in all tissue types examined. Isoform 5 appears to be more abundant in the brain. Isoform 4 is predominant in the liver, skeletal muscle and placenta.
配列類似性Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Contains 1 CNH domain. Contains 1 protein kinase domain.
翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.