Anti-Mannan Binding Lectin/MBL 抗体 [11C9] (ab26277)
Key features and details
- Mouse monoclonal [11C9] to Mannan Binding Lectin/MBL
- Suitable for: ELISA, IP, WB
- Reacts with: Human
- Isotype: IgG1
製品の概要
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製品名
Anti-Mannan Binding Lectin/MBL antibody [11C9]
Mannan Binding Lectin/MBL 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [11C9] to Mannan Binding Lectin/MBL -
由来種
Mouse -
特異性
ab26277 reacts with human Mannan binding lectin/MBL both in its polymeric state and as a single subunit of molecular mass 26 kDa. It reacts with Mannan binding lectin/MBL from serum and plasma.
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アプリケーション
適用あり: ELISA, IP, WBmore details -
種交差性
交差種: Human -
免疫原
Full length protein corresponding to Human Mannan Binding Lectin/MBL.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.40
Preservative: 0.097% Sodium azide
Constituents: 0.0268% PBS, 2.9% Sodium chloride -
Concentration information loading...
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特記事項(精製)
Protein A/G purified -
ポリ/モノ
モノクローナル -
クローン名
11C9 -
ミエローマ
x63-Ag8.653 -
アイソタイプ
IgG1 -
軽鎖の種類
kappa -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab26277の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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ELISA |
Use at an assay dependent concentration.
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IP |
Use at an assay dependent concentration.
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WB |
Use at an assay dependent concentration.
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特記事項 |
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ELISA
Use at an assay dependent concentration. |
IP
Use at an assay dependent concentration. |
WB
Use at an assay dependent concentration. |
ターゲット情報
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機能
Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. -
組織特異性
Plasma protein produced mainly in the liver. -
関連疾患
Note=There is an association between low levels of MBL2 and a defect of opsonization which results in susceptibility to frequent and chronic infections. -
配列類似性
Contains 1 C-type lectin domain.
Contains 1 collagen-like domain. -
細胞内局在
Secreted. - Information by UniProt
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参照データベース
- Entrez Gene: 4153 Human
- Omim: 154545 Human
- SwissProt: P11226 Human
- Unigene: 499674 Human
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別名
- COLEC 1 antibody
- COLEC1 antibody
- Collectin-1 antibody
see all
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (6)
ab26277 は 6 報の論文で使用されています。
- Liu Y et al. MBL Binding with AhR Controls Th17 Immunity in Silicosis-Associated Lung Inflammation and Fibrosis. J Inflamm Res 15:4315-4329 (2022). PubMed: 35923908
- Bhute VJ et al. Mannose Binding Lectin Is Hydroxylated by Collagen Prolyl-4-hydroxylase and Inhibited by Some PHD Inhibitors. Kidney360 1:447-457 (2020). PubMed: 35368589
- Bibert S et al. Herpes simplex encephalitis in adult patients with MASP-2 deficiency. PLoS Pathog 15:e1008168 (2019). PubMed: 31869396
- Harboe M et al. Design of a complement mannose-binding lectin pathway-specific activation system applicable at low serum dilutions. Clin Exp Immunol 144:512-20 (2006). PubMed: 16734621
- Larsen F et al. Disease-associated mutations in human mannose-binding lectin compromise oligomerization and activity of the final protein. J Biol Chem 279:21302-11 (2004). PubMed: 14764589
- Downing I et al. Immature dendritic cells possess a sugar-sensitive receptor for human mannan-binding lectin. Immunology 109:360-4 (2003). PubMed: 12807481