製品の概要

  • 製品名Anti-MAN1 antibody
    MAN1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to MAN1
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    Synthetic peptide corresponding to 18 amino acids near the C-terminus of Human MAN1 (NP_055134).

  • ポジティブ・コントロール
    • Human colon tissue lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab124148 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 100 kDa.
IHC-P Use a concentration of 2.5 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

ターゲット情報

  • 機能Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest.
  • 組織特異性Heart, brain, placenta, lung, liver and skeletal muscle.
  • 関連疾患Defects in LEMD3 are the cause of Buschke-Ollendorff syndrome (BOS) [MIM:166700]; also known as dermatoosteopoikilosis or disseminated dermatofibrosis with osteopoikilosis or dermatofibrosis lenticularis disseminata with osteopoikilosis or osteopathia condensans disseminata. BOS refers to the association of osteopoikilosis with disseminated connective-tissue nevi. Osteopoikilosis is a skeletal dysplasia characterized by a symmetric but unequal distribution of multiple hyperostotic areas in different parts of the skeleton. Both elastic-type nevi (juvenile elastoma) and collagen-type nevi (dermatofibrosis lenticularis disseminata) have been described in BOS. Skin or bony lesions can be absent in some family members, whereas other relatives may have both.
    Defects in LEMD3 are a cause of melorheostosis (MEL) [MIM:155950]. Melorheostosis is a rare mesenchymal dysplasia and one of the sclerosing bone disorders. It is caused by a developmental error, with a sclerotomal distribution, frequently involving one limb. It may be asymptomatic, but pain, stiffness with limitation of motion, leg-length discrepancy and limb deformity may occur.
  • 配列類似性Contains 1 LEM domain.
  • 細胞内局在Nucleus inner membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Inner nuclear membrane protein Man1 antibody
    • LEM domain containing protein 3 antibody
    • LEM domain-containing protein 3 antibody
    • LEMD3 antibody
    • MAN1_HUMAN antibody
    see all

Anti-MAN1 antibody 画像

  • Anti-MAN1 antibody (ab124148) at 2 µg/ml + Human colon tissue lysate at 15 µg

    Predicted band size : 100 kDa
  • Immunohistochemical analysis of Human colon tissue, staining MAN1 with ab124148 at 2.5 µg/ml.

Anti-MAN1 antibody (ab124148) 使用論文

ab124148 has not yet been referenced specifically in any publications.

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