Anti-Malignant T cell amplified sequence 1 抗体 (ab89839)

製品の概要

  • 製品名Anti-Malignant T cell amplified sequence 1 antibody
    Malignant T cell amplified sequence 1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Malignant T cell amplified sequence 1
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 2-51 (FKKFDEKENV SNCIQLKTSV IKGIKNQLIE QFPGIEPWLN QIMPKKDPVK) of Human Malignant T cell amplified sequence 1 (NP_054779).

  • ポジティブ・コントロール
    • COLO205 cell lysate.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab89839 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 21 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能Anti-oncogene that play a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Plays a role as translation enhancer; Recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; Up-regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when over-expressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines over-expressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3.
  • 組織特異性Ubiquitous. Over-expressed in T-cell lymphoid cell lines and in non-Hodgkin lymphoma cell lines as well as in a subset of primary large B-cell lymphomas.
  • 配列類似性Belongs to the MCTS1 family.
    Contains 1 PUA domain.
  • ドメインThe PUA RNA-binding domain is critical for cap binding, but not sufficient for translation enhancer function. MCT1 N-terminal region is required to enhance translation possibly trough interaction with other proteins.
  • 翻訳後修飾Phosphorylation is critical for stabilization and promotion of cell proliferation.
  • 細胞内局在Cytoplasm. Nuclear relocalization after DNA damage.
  • Information by UniProt
  • 参照データベース
  • 別名
    • FLJ39637 antibody
    • Malignant T cell-amplified sequence 1 antibody
    • MCT 1 antibody
    • MCT-1 antibody
    • MCT1 antibody
    • MCTS 1 antibody
    • MCTS1 antibody
    • MCTS1_HUMAN antibody
    • Multiple copies T cell malignancies 1 antibody
    • Multiple copies T cell malignancies antibody
    • Multiple copies T-cell malignancies antibody
    • Oncogene MCT 1 antibody
    • Oncogene MCT1 antibody
    see all

Anti-Malignant T cell amplified sequence 1 antibody 画像

  • Anti-Malignant T cell amplified sequence 1 antibody (ab89839) at 1 µg/ml (in 5% skim milk / PBS buffer) + COLO205 cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 21 kDa

Anti-Malignant T cell amplified sequence 1 antibody (ab89839) 使用論文

ab89839 has not yet been referenced specifically in any publications.

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