製品の概要

  • 製品名Anti-MAK antibody
    MAK 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to MAK
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment: PPKQQSQEKP PQTLFPSIVK NMPTKPNGTL SHKSGRRRWG QTIFKSGDSW EELEDYDFGA SHSKKPSMGV FKEKRKKDSP FRQQVKMAVI SLSAHQFPTL , corresponding to amino acids 358-457 of Human MAK

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • 精製度Protein G purified
  • ポリ/モノモノクローナル
  • アイソタイプIgG2a
  • 軽鎖の種類kappa
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab55453 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報WB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors (By similarity). Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR. Could play an important function in spermatogenesis. May play a role in chromosomal stability in prostate cancer cells.
    • 組織特異性Expressed in prostate cancer cell lines at generally higher levels than in normal prostate epithelial cell lines. Isoform 1 is expressed in kidney, testis, lung, trachea, and retina. Isoform 2 is retina-specific where it is expressed in rod and cone photoreceptors.
    • 関連疾患Defects in MAK are the cause of retinitis pigmentosa type 62 (RP62) [MIM:614181]. RP62 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
    • 配列類似性Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
      Contains 1 protein kinase domain.
    • 翻訳後修飾Autophosphorylated. Phosphorylated on serine and threonine residues.
    • 細胞内局在Nucleus. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > spindle. Midbody. Cell projection > cilium > photoreceptor outer segment. Photoreceptor inner segment. Localized in both the connecting cilia and the outer segment axonemes (By similarity). Localized uniformly in nuclei during interphase, to the mitotic spindle and centrosomes during metaphase and anaphase, and also to midbody at anaphase until telophase.
    • Information by UniProt
    • 参照データベース
    • 別名
      • intestinal cell kinase antibody
      • dJ417M14.2 antibody
      • fj04c02 antibody
      • Ick antibody
      • Mak antibody
      • MAK_HUMAN antibody
      • Male germ cell associated kinase antibody
      • Male germ cell-associated kinase antibody
      • male germ cell-associated kinase retinal-enriched isoform antibody
      • OTTHUMP00000016025 antibody
      • Rck antibody
      • RP62 antibody
      • Serine/threonine protein kinase MAK antibody
      • Serine/threonine-protein kinase MAK antibody
      • testicular secretory protein Li 28 antibody
      • wu:fj04c02 antibody
      • zgc:56603 antibody
      see all

    Anti-MAK antibody 画像



    • Predicted band size : 71 kDa
      MAK antibody (ab55453) at 1ug/lane + HepG2 cell lysate at 25ug/lane.

    Anti-MAK antibody (ab55453) 使用論文

    ab55453 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab55453.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"