製品の概要

  • 製品名Anti-MAGOH antibody
    MAGOH 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to MAGOH
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 45-74 of Human MAGOH (NP_002361.1).

  • ポジティブ・コントロール
    • K-562 cell line lysates

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab123399 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 17 kDa.

ターゲット情報

  • 機能Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction in the mature mRNA and thereby influences downstream processes of gene expression including mRNA splicing, nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Remains associated with the mRNA after its export to the cytoplasm and require translation of the mRNA for removal. The heterodimer MAGOH-RBM8A interacts with PYM that function to enhance the translation of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex.
  • 組織特異性Ubiquitous.
  • 配列類似性Belongs to the mago nashi family.
  • 細胞内局在Nucleus. Nucleus speckle. Cytoplasm. Detected in granule-like structures in the dendroplasm (By similarity). Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Colocalizes with the core EJC, THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Mago nashi homolog proliferation associated (Drosophila) antibody
    • Mago nashi protein homolog antibody
    • magoh antibody
    • MAGOHA antibody
    • MGN_HUMAN antibody
    • Protein mago nashi homolog antibody
    see all

Anti-MAGOH antibody 画像

  • Anti-MAGOH antibody (ab123399) at 1/100 dilution + K-562 cell line lysates at 35 µg

    Predicted band size : 17 kDa

Anti-MAGOH antibody (ab123399) 使用論文

ab123399 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"