製品の概要

  • 製品名Anti-MAGI3 antibody
    MAGI3 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to MAGI3
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Recombinant fragment, corresponding to amino acids 716-979 of Human MAGI3 (BC130409).

  • ポジティブ・コントロール
    • Human fetal brain, fetal kidney and fetal liver lysates; Human fetal testis tissue.

製品の特性

  • 製品の状態Lyophilised:Reconstitute in 200 µl sterile distilled water.
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • バッファーpH: 7.20
    Preservative: 0.02% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)ab118615 is purified by protein affinity column.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab118615 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Detects a band of approximately 130, 160 kDa (predicted molecular weight: 123, 160 kDa).
IHC-P 1/100 - 1/500.

ターゲット情報

  • 機能Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2.
  • 組織特異性Widely expressed.
  • 配列類似性Belongs to the MAGUK family.
    Contains 1 guanylate kinase-like domain.
    Contains 6 PDZ (DHR) domains.
    Contains 2 WW domains.
  • 翻訳後修飾Ubiquitinated following interaction with HPV E6 protein, leading to its degradation by the proteasome. Degradation is independent of E6AP ubiquitin ligase complex.
  • 細胞内局在Cell membrane. Cell junction > tight junction. Nucleus. Concentrates in specific sites at the plasma membrane and in the nucleus. In epithelial cells, it localizes at tight junctions.
  • Information by UniProt
  • 参照データベース
  • 別名
    • dJ730K3.2 antibody
    • MAGI-3 antibody
    • magi3 antibody
    • MAGI3_HUMAN antibody
    • Membrane Associated Guanylate kinase Related 3 antibody
    • Membrane-associated guanylate kinase antibody
    • Membrane-associated guanylate kinase inverted 3 antibody
    • RP4-730K3.1 antibody
    • SLIPR antibody
    • WW and PDZ domain-containing protein 3 antibody
    see all

Anti-MAGI3 antibody 画像

  • All lanes : Anti-MAGI3 antibody (ab118615) at 1/500 dilution

    Lane 1 : Human fetal brain lysate
    Lane 2 : Human fetal kidney lysate
    Lane 3 : Human fetal liver lysate


    Predicted band size : 123, 160 kDa
    Observed band size : 130,160 kDa (why is the actual band size different from the predicted?)
  • ab118615 at 1/100 dilution, staining MAGI3 in formalin fixed, paraffin embedded Human fetal testis tissue by Immunohistochemistry. Note membrane and nuclear staining.

Anti-MAGI3 antibody (ab118615) 使用論文

ab118615 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab118615.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"