製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to MAGED1
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Rat
    交差が予測される動物種: Human
  • 免疫原

    Synthetic peptide corresponding to Mouse MAGED1 aa 683-699 conjugated to Keyhole Limpet Haemocyanin (KLH).
    Sequence:

    C-EAEARAEARNRMGIGDE

  • ポジティブ・コントロール
    • PC12 cell extracts

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • バッファー
    Preservative: 0.02% Sodium Azide
    Constituents: 50% Glycerol, PBS (without Mg2+ and Ca2+), 150mM Sodium chloride, pH 7.4
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab104627 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Predicted molecular weight: 86 kDa.

ターゲット情報

  • 機能
    Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed.
  • 組織特異性
    Expressed in bone marrow stromal cells from both multiple myeloma patients and healthy donors. Seems to be ubiquitously expressed.
  • 配列類似性
    Contains 1 MAGE domain.
  • 細胞内局在
    Cytoplasm. Cell membrane. Nucleus. Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF.
  • Information by UniProt
  • 参照データベース
  • 別名
    • DLXIN 1 antibody
    • MAGD1_HUMAN antibody
    • MAGE D1 antigen antibody
    • MAGE tumor antigen CCF antibody
    • MAGE-D1 antigen antibody
    • Maged1 antibody
    • Melanoma antigen family D 1 antibody
    • Melanoma associated antigen D1 antibody
    • Melanoma-associated antigen D1 antibody
    • Neurotrophin receptor interacting MAGE homolog antibody
    • Neurotrophin receptor-interacting MAGE homolog antibody
    • NRAGE antibody
    • PP2250 antibody
    see all

画像

  • All lanes : Anti-MAGED1 antibody (ab104627) at 1/500 dilution

    Lane 1 : PC12 cell extracts with MAGED1 blocking peptide
    Lane 2 : PC12 cell extracts


    Predicted band size : 86 kDa

プロトコール

参考文献

ab104627 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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