Anti-MafB 抗体 (ab56242)

製品の概要

• 製品名Anti-MafB antibody
  MafB 一次抗体 製品一覧
• 製品の詳細
  Rabbit polyclonal to MafB
• アプリケーション適用あり: WB, IHC-Pmore details
• 種交差性
  交差種: Human
  交差が予測される動物種: Mouse, Rat, Rabbit, Chicken, Guinea pig, Cow, Cat, Zebrafish
• 免疫原

  Synthetic peptide corresponding to a region of Human MAFB

• ポジティブ･コントロール
  • ウェスタン・ブロット用ポジティブコントロールRecombinant Human MafB protein
  • HepG2 cell lysate; human spleen tissue

製品の特性

• 製品の状態Liquid
• 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• バッファーPreservative: None
  Constituents: 2% Sucrose, PBS
• Concentration information loading...
• 精製度Immunogen affinity purified
• ポリ/モノポリクローナル
• アイソタイプIgG
• 研究分野
  • Epigenetics and Nuclear Signaling
  • Transcription
  • Domain Families
  • HLH / Leucine Zipper
  • Leucine Zipper

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Transcription Factors

関連製品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Positive Controls
  • HepG2 nuclear extract lysate (ab14660)

アプリケーション

ターゲット情報

• 機能Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity). Involved either as an oncogene or as a tumor suppressor, depending on the cell context.
• 組織特異性Ubiquitous.
• 関連疾患Defects in MAFB are the cause of multicentric carpotarsal osteolysis syndrome (MCTO) [MIM:166300]. MCTO is a rare skeletal disorder, usually presenting in early childhood with a clinical picture mimicking juvenile rheumatoid arthritis. Progressive destruction of the carpal and tarsal bone usually occurs and other bones may also be involved. Chronic renal failure is a frequent component of the syndrome. Mental retardation and minor facial anomalies have been noted in some patients.
• 配列類似性Belongs to the bZIP family. Maf subfamily.
  Contains 1 bZIP domain.
• ドメインThe leucine-zipper domain is involved in the interaction with LRPICD.
• 翻訳後修飾Phosphorylated by GSK3 and MAPK13 on serine and threonine residues.
  Sumoylated. Sumoylation on Lys-32 and Lys-297 stimulates its transcriptional repression activity and promotes macrophage differentiation from myeloid progenitors.
• 細胞内局在Nucleus.

• Target information above from: UniProt accession Q9Y5Q3 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 9935 Human
  • Entrez Gene: 16658 Mouse
  • Entrez Gene: 54264 Rat
  • Entrez Gene: 30210 Zebrafish
  • GenBank: AF134157.1 Human
  • Omim: 608968 Human
  • SwissProt: Q9Y5Q3 Human
  • SwissProt: P54841 Mouse

  • SwissProt: P54842 Rat
  • SwissProt: Q98UK5 Zebrafish
  • Unigene: 169487 Human
  • Unigene: 651210 Human
  • Unigene: 330745 Mouse
  • Unigene: 10725 Rat
  • Unigene: 75475 Zebrafish

  see all
• 別名
  • Kreisler antibody
  • Kreisler (mouse) maf related leucine zipper homolog antibody
  • Kreisler maf related leucine zipper homolog antibody

  • KRML antibody
  • Maf-B antibody
  • Mafb antibody
  • MAFB/Kreisler basic region/leucine zipper transcription factor antibody
  • MAFB_HUMAN antibody
  • MGC43127 antibody
  • Segmentation protein KR antibody
  • Transcription factor MafB antibody
  • V maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) antibody
  • V-maf musculoaponeurotic fibrosarcoma oncogene homolog B antibody

  see all