Anti-MAFA 抗体 (ab85008)
Key features and details
- Rabbit polyclonal to MAFA
- Suitable for: IHC-P
- Reacts with: Mouse
- Isotype: IgG
製品の概要
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製品名
Anti-MAFA antibody
MafA 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to MAFA -
由来種
Rabbit -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Mouse -
免疫原
Synthetic peptide corresponding to Mouse MafA aa 300-400 (C terminal).
Database link: Q8CF90 -
ポジティブ・コントロール
- Mouse Pancreas tissue.
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特記事項
Concentration is optimized for IHC and not determined
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 6.8
Preservative: 0.09% Sodium azide
Constituents: Tris buffered saline, 0.1% BSA -
Concentration information loading...
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精製度
Immunogen affinity purified -
特記事項(精製)
ab85008 was affinity purified using the peptide immobilized on solid support. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab85008の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
IHC-P | (1) |
特記事項 |
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Likely to work with frozen sections.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
ターゲット情報
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機能
Acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b and activates insulin gene expression. Cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. -
配列類似性
Belongs to the bZIP family. Maf subfamily.
Contains 1 bZIP domain. -
翻訳後修飾
Ubiquitinated, leading to its degradation by the proteasome.
Ser-14 and Ser-65 appear to be the major phosphorylation sites. Phosphorylated by MAPK13 on serine and threonine residues (Probable). Phosphorylation by GSK3 requires prior phosphorylation of Ser-65 by another kinase. Phosphorylation proceeds then from Ser-61 to Thr-57, Thr-53 and Ser-49. GSK3-mediated phosphorylation increases its transcriptional activity through the recruitment of the coactivator PCAF, is required for its transforming activity and leads to its degradation through an ubiquitin/proteasome-dependent pathway. -
細胞内局在
Nucleus. Detected in nuclei of pancreas islet beta cells. - Information by UniProt
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参照データベース
- Entrez Gene: 378435 Mouse
- SwissProt: Q8CF90 Mouse
- Unigene: 309589 Mouse
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別名
- HMafA antibody
- Mafa antibody
- MAFA_HUMAN antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (0)
ab85008 は論文での使用が確認できていません。