製品の概要

  • 製品名Anti-MAFA antibody
    MafA 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to MAFA
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a sequence between C terminal amino acids 285-315 of Human MafA (NP_963883.2).

  • ポジティブ・コントロール
    • K-562 cell line lysates

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab124108 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 37 kDa.

ターゲット情報

  • 機能Acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b and activates insulin gene expression. Cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity. Involved either as an oncogene or as a tumor suppressor, depending on the cell context.
  • 配列類似性Belongs to the bZIP family. Maf subfamily.
    Contains 1 bZIP domain.
  • 翻訳後修飾Ubiquitinated, leading to its degradation by the proteasome.
    Ser-14 and Ser-65 appear to be the major phosphorylation sites. Phosphorylated by MAPK13 on serine and threonine residues (Probable). Phosphorylation by GSK3 requires prior phosphorylation of Ser-65 by another kinase. Phosphorylation proceeds then from Ser-61 to Thr-57, Thr-53 and Ser-49. GSK3-mediated phosphorylation increases its transcriptional activity through the recruitment of the coactivator PCAF, is required for its transforming activity and leads to its degradation through an ubiquitin/proteasome-dependent pathway.
  • 細胞内局在Nucleus. Detected in nuclei of pancreas islet beta cells.
  • Information by UniProt
  • 参照データベース
  • 別名
    • HMafA antibody
    • Mafa antibody
    • MAFA_HUMAN antibody
    • Pancreatic beta cell specific transcriptional activator antibody
    • Pancreatic beta-cell-specific transcriptional activator antibody
    • RIPE3b1 antibody
    • Transcription factor MafA antibody
    • Transcription factor RIPE3b1 antibody
    • v maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) antibody
    • v maf musculoaponeurotic fibrosarcoma oncogene homolog A antibody
    • V-maf musculoaponeurotic fibrosarcoma oncogene homolog A antibody
    see all

Anti-MAFA antibody 画像

  • Anti-MAFA antibody (ab124108) at 1/100 dilution + K-562 cell line lysates at 35 µg

    Predicted band size : 37 kDa

Anti-MAFA antibody (ab124108) 使用論文

ab124108 has not yet been referenced specifically in any publications.

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