製品の概要

  • 製品名Anti-MAdCAM1 antibody [MECA-367] (FITC)
    MAdCAM1 一次抗体 製品一覧
  • 製品の詳細
    Rat monoclonal [MECA-367] to MAdCAM1 (FITC)
  • 標識FITC. Ex: 493nm, Em: 528nm
  • アプリケーション適用あり: Blocking, Flow Cyt, IHC-Fr, IP, WB, Othermore details
  • 種交差性
    交差種: Mouse
  • 免疫原

    Tissue/ cell preparation: Endothelial cells isolated from BALB/c mouse mesenteric and peripheral lymph nodes.

  • エピトープThis antibody reacts with an epitope located in the first domain of MAdCAM1.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab24941 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Blocking
Flow Cyt
IHC-Fr
IP
WB
AP
Other
  • 追加情報AP: Use at an assay dependent dilution.
    BL: Use at an assay dependent dilution.
    Note: This antibody is useful for in vitro cellular binding blocking, and for blocking lymphocyte homing to Peyers patch HEV in vivo.
    Flow Cyt: Use at an assay dependent dilution.
    IHC-Fr: Use at a concentration of 1 µg/ml.
    IP: Use at an assay dependent dilution.
    WB: Use at an assay dependent dilution. Predicted molecular weight: 44 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.
    • 組織特異性Highly expressed on high endothelial venules (HEV) and lamina propia venules found in the small intestine, and to a lesser extent in the colon and spleen. Very low levels of expression found in pancreas and brain. Not expressed in the thymus, prostate, ovaries, testis, heart, placenta, lung, liver, skeletal muscle, kidney or peripheral blood leukocytes.
    • 配列類似性Contains 2 Ig-like (immunoglobulin-like) domains.
    • 翻訳後修飾The Ser/Thr-rich mucin-like domain may provide possible sites for O-glycosylation.
    • 細胞内局在Membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Addressin mucosal antibody
      • hMAdCAM 1 antibody
      • hMAdCAM-1 antibody
      • MACAM1 antibody
      • MADCA_HUMAN antibody
      • MAdCAM 1 antibody
      • MAdCAM-1 antibody
      • Madcam1 antibody
      • Mucosal addressin cell adhesion molecule 1 antibody
      • Mucosal vascular addressin cell adhesion molecule 1 antibody
      see all

    Anti-MAdCAM1 antibody [MECA-367] (FITC) (ab24941) 使用論文

    This product has been referenced in:
    • Hwang IY  et al. The loss of Gnai2 and Gnai3 in B cells eliminates B lymphocyte compartments and leads to a hyper-IgM like syndrome. PLoS One 8:e72596 (2013). IHC-Fr ; Mouse . Read more (PubMed: 23977324) »

    See 1 Publication for this product

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